Publications by authors named "Myriam Khalili"
Background: While there is increasing reliance on a negative virtual crossmatch to proceed with deceased donor kidney transplantation, a flow cytometry crossmatch (FCXM) is still usually performed after the transplant has already occurred. Our center has eliminated pretransplant physical crossmatches for most patients, and since 2018, we have eliminated the systematic performance of posttransplant FCXMs.
Methods: We studied all deceased donor kidney transplants in our program between June 1, 2018, and March 31, 2021, to evaluate the impact of eliminating retrospective FCXMs on resource utilization and graft outcomes (ie, the occurrence of antibody-mediated rejection [AMR] in the first 3-mo posttransplant).
Article Synopsis
- The study examines the role of different complement activation pathways—classical, lectin, and alternative—in five types of autoimmune glomerulonephritis (GN) to understand which pathway is more active and could be targeted for therapy.
- Researchers monitored 112 patients over a median of 22 months, assessing various urinary complement biomarkers to see how they correlated with disease severity, particularly focusing on proteinuria levels.
- Findings suggest that both the alternative pathway and classical/lectin pathways influence the terminal pathway's activation in autoimmune GN, identifying them as promising targets for future treatments.
Background: The decision to accept a kidney from a deceased donor can be a difficult one. This study aims to capture the perspectives of transplant candidates (TCs) and kidney transplant recipients (KTRs) on the decision-making process when a deceased kidney is offered.
Methods: We conducted six focus groups with KTRs and TCs.
Introduction: Complement activation, inflammation, and fibrosis play central roles in the mechanisms of injury in autoimmune glomerulonephritis (GN) but they are seldom assessed in epidemiologic studies. The measurement of urinary biomarkers of these pathways of injury could parallel disease activity and add clinical value beyond proteinuria.
Methods: We performed a prospective cohort study of 100 patients with focal and segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), IgA nephropathy (IgAN), lupus nephritis (LN), anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV), and membranoproliferative GN (MPGN) followed for 33 (18-54) months.
Background: The debate over acetylsalicylic acid (ASA) therapy for primary prevention of cardiovascular disease (CVD) has recently resurfaced, but scarce data are available on prophylactic ASA use in Canada for this purpose. This study aimed to evaluate the prevalence and factors associated with ASA use, and the potential impact of implementing the most recent (2016) US Preventive Services Task Force recommendations for primary CVD prevention in a Canadian setting.
Methods: We performed a cross-sectional analysis using data from the CARTaGENE study, which included a representative sample ( = 20 004) of the 2018 general population of the province of Quebec.
The adoptive transfer of -expanded T cells is a promising approach to treat several malignancies. Several lines of evidence support that the infusion of T cells with early memory features, capable of expanding and persisting after transfer, are associated with better outcomes. We report herein that exposure to exogenous TGFβ during human T-cell stimulation leads to the accumulation of early/central memory (Tcm) cells.
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