Publications by authors named "Myriam Dubois"
Background: Characterisation of human-associated viral communities is essential for epidemiological surveillance and to be able to anticipate new potential threats for blood transfusion safety. In high-resource countries, the risk of blood-borne agent transmission of well-known viruses (HBV, HCV, HIV and HTLV) is currently considered to be under control. However, other unknown or unsuspected viruses may be transmitted to recipients by blood-derived products.
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- - Yeasts, particularly Pichia pastoris, are being explored as a dual system for producing and delivering malaria vaccines using the circumsporozoite protein (CS) from the Plasmodium berghei parasite, avoiding high purification costs and safety concerns with adjuvants.
- - The N-PbCS fusion protein created in yeast forms multimeric ribonucleoprotein rods, which were shown to elicit a significant immune response in C57Bl/6 mice, leading to reduced infection severity.
- - This strategy not only demonstrates the effectiveness of whole yeast as an intrinsic adjuvant but also opens the door for developing multivalent vaccine formulations that could improve malaria immunization efforts.