Publications by authors named "Myriam Abdallah"
Background: Aryl phosphate esters (APEs) are widely used and commonly present in the environment. Health hazards associated with these compounds remain largely unknown and the effects of diphenyl phosphate (DPhP), one of their most frequent derivatives, are poorly characterized.
Objective: Our aim was to investigate whether DPhP per se may represent a more relevant marker of exposure to APEs than direct assessment of their concentration and determine its potential deleterious biological effects in chronically exposed mice.
Article Synopsis
- Kinase inhibitors, like dasatinib, are promising for targeted cancer therapy but also have effects on the immune system, particularly T-cells and NK-cells.
- Research suggests dasatinib may also affect non-conventional T-αβ cell subsets, such as iNKT and a new CD8 T-cell subset, by promoting an activated and anti-tumor phenotype.
- In both mice and humans, dasatinib treatment increased the frequency of these innate T-cell subsets, showing its potential to enhance immune responses and paving the way for combined chemotherapy and immunotherapy approaches.
Unconventional T cells are defined by their capacity to respond to signals other than the well-known complex of peptides and major histocompatibility complex proteins. Among the burgeoning family of unconventional T cells, innate-like CD8(+) T cells in the mouse were discovered in the early 2000s. This subset of CD8(+) T cells bears a memory phenotype without having encountered a foreign antigen and can respond to innate-like IL-12 + IL-18 stimulation.
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