Publications by authors named "Myong Suk Ko"
Lamivudine belongs to the set of antiviral agents effective against hepatitis B virus infection. Given case reports on liver injuries after certain antiviral agent treatments, this study examined the effects of lamivudine on alanine aminotransferase (ALT) and total bilirubin (TB) using a medical system database. A total of 1,321 patients taking lamivudine alone or with others were evaluated using laboratory hits in an electronic medical system at Seoul National University Hospital from 2005 through 2011.
View Article and Find Full Text PDFTacrolimus therapy causes hepatotoxicity in patients with a history of liver disease.
Int J Clin Pharmacol Ther
May 2015
Objective: Tacrolimus is known to have little hepatotoxicity. Nevertheless, a few case studies have shown liver toxicities of tacrolimus, particularly in patients on multiple medications. This study is a retrospective data analysis on the potential of tacrolimus hepatotoxicity.
View Article and Find Full Text PDFArticle Synopsis
- Oltipraz promotes cancer prevention by inducing glutathione S-transferase (GST) through the activation of CCAAT/enhancer binding protein-beta (C/EBPbeta) and nuclear accumulation of NF-E2-related factor-2 (Nrf2).
- The study found that two major oxidized metabolites of oltipraz (M1 and M2) effectively induce the GSTA2 gene, while M3 and M4 do not have this effect.
- M1 activates GSTA2 primarily through C/EBPbeta, while M2 activates it by both C/EBPbeta and Nrf2, showcasing the varying impacts of different oltipraz metabolites on gene induction.