Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes.

Context: Visceral adipose tissue (VAT) is a key contributor to chronic inflammation in obesity. The 12/15-lipoxygenase pathway (ALOX) is present in adipose tissue (AT) and leads to inflammatory cascades that are causal for the onset of insulin resistance in rodent models of obesity.

Objective: The pathophysiology of the ALOX 12/15 pathway in human AT is unknown.