Security Evaluation of Companion Android Applications in IoT: The Case of Smart Security Devices.

Smart security devices, such as smart locks, smart cameras, and smart intruder alarms are increasingly popular with users due to the enhanced convenience and new features that they offer. A significant part of this convenience is provided by the device's companion smartphone app. Information on whether secure and ethical development practices have been used in the creation of these applications is unavailable to the end user.

CBCT-DRRs superior to CT-DRRs for target-tracking applications for pancreatic SBRT.

In current radiograph-based intra-fraction markerless target-tracking, digitally reconstructed radiographs (DRRs) from planning CTs (CT-DRRs) are often used to train deep learning models that extract information from the intra-fraction radiographs acquired during treatment. Traditional DRR algorithms were designed for patient alignment (bone matching) and may not replicate the radiographic image quality of intra-fraction radiographs at treatment. Hypothetically, generating DRRs from pre-treatment Cone-Beam CTs (CBCT-DRRs) with DRR algorithms incorporating physical modelling of on-board-imagers (OBIs) could improve the similarity between intra-fraction radiographs and DRRs by eliminating inter-fraction variation and reducing image-quality mismatches between radiographs and DRRs.

AALLA: Attack-Aware Logical Link Assignment Cost-Minimization Model for Protecting Software-Defined Networks against DDoS Attacks.

Software-Defined Networking (SDN), which is used in Industrial Internet of Things, uses a controller as its "network brain" located at the control plane. This uniquely distinguishes it from the traditional networking paradigms because it provides a global view of the entire network. In SDN, the controller can become a single point of failure, which may cause the whole network service to be compromised.

Realistic CT data augmentation for accurate deep-learning based segmentation of head and neck tumors in kV images acquired during radiation therapy.

Background: Using radiation therapy (RT) to treat head and neck (H&N) cancers requires precise targeting of the tumor to avoid damaging the surrounding healthy organs. Immobilisation masks and planning target volume margins are used to attempt to mitigate patient motion during treatment, however patient motion can still occur. Patient motion during RT can lead to decreased treatment effectiveness and a higher chance of treatment related side effects.

Optical imaging of the small intestine immune compartment across scales.

The limitations of 2D microscopy constrain our ability to observe and understand tissue-wide networks that are, by nature, 3-dimensional. Optical projection tomography (OPT) enables the acquisition of large volumes (ranging from micrometres to centimetres) in various tissues. We present a multi-modal workflow for the characterization of both structural and quantitative parameters of the mouse small intestine.

Deep learning enables MV-based real-time image guided radiation therapy for prostate cancer patients.

. Using MV images for real-time image guided radiation therapy (IGRT) is ideal as it does not require additional imaging equipment, adds no additional imaging dose and provides motion data in the treatment beam frame of reference. However, accurate tracking using MV images is challenging due to low contrast and modulated fields.

Evaluation of deep learning based implanted fiducial markers tracking in pancreatic cancer patients.

Real-time target position verification during pancreas stereotactic body radiation therapy (SBRT) is important for the detection of unplanned tumour motions. Fast and accurate fiducial marker segmentation is a Requirement of real-time marker-based verification. Deep learning (DL) segmentation techniques are ideal because they don't require additional learning imaging or prior marker information (e.

Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea.

Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cleaves cathelicidin antimicrobial peptide, are key pathogenic triggers in rosacea. However, how these events are linked to the disease remains unknown.

The significance of double mandibular osteotomy for surgical treatment of large aneurysm of internal carotid artery above mandibular angle. A case report and literature review.

The aim of this study is to report a case of an unusual large aneurysm of the internal carotid approached with a doubly mandibular osteotomy in order to prove the significance and the excellent result of the specified surgical procedure because of the cooperation of maxillofacial and vascular surgeons. The double mandibular osteotomy is described, as well as the bypass of the aneurysm and the anastomosis of the peripheral edges of the artery. The double mandibular osteotomy can deliver the internal carotid artery from the bifurcation to its entrance to the skull base through the carotid canal and can offer the opportunity to the vascular surgeon to perform the anastomosis easily, quickly and safely.

Cellular Senescence and Ageing: Mechanisms and Interventions.

The influence of the activation of a cellular phenotype termed senescence and it's importance in ageing and age-related diseases is becoming more and more evident. In fact, there is a huge effort to tackle these diseases via therapeutic drugs targeting senescent cells named senolytics. However, a clearer understanding of how senescence is activated and the influence it has on specific cellular types and tissues is needed.

A Robust Dirichlet Reputation and Trust Evaluation of Nodes in Mobile Ad Hoc Networks.

The distributed nature of mobile ad hoc networks (MANETs) presents security challenges and vulnerabilities which sometimes lead to several forms of attacks. To improve the security in MANETs, reputation and trust management systems (RTMS) have been developed to mitigate some attacks and threats arising from abnormal behaviours of nodes in networks. Generally, most reputation and trust systems in MANETs focus mainly on penalising uncooperative network nodes.

Management of transthyretin amyloidosis.

Transthyretin amyloidosis (ATTR amyloidosis) is a disease caused by deposition of transthyretin fibrils in organs and tissues, which causes their dysfunction. The clinical heterogeneity of ATTR amyloidosis and the variable presentation of symptoms at early disease stages, historically meant treatment delays. Diagnostic tools and therapy options of ATTR amyloidosis have markedly improved in recent years.

A review of artificial intelligence applications for motion tracking in radiotherapy.

During radiotherapy, the organs and tumour move as a result of the dynamic nature of the body; this is known as intrafraction motion. Intrafraction motion can result in tumour underdose and healthy tissue overdose, thereby reducing the effectiveness of the treatment while increasing toxicity to the patients. There is a growing appreciation of intrafraction target motion management by the radiation oncology community.

High resolution optical projection tomography platform for multispectral imaging of the mouse gut.

Optical projection tomography (OPT) is a powerful tool for three-dimensional imaging of mesoscopic biological samples with great use for biomedical phenotyping studies. We present a fluorescent OPT platform that enables direct visualization of biological specimens and processes at a centimeter scale with high spatial resolution, as well as fast data throughput and reconstruction. We demonstrate nearly isotropic sub-28 µm resolution over more than 60 mm after reconstruction of a single acquisition.

A Comparative Analysis of Honeypots on Different Cloud Platforms.

In 2019, the majority of companies used at least one cloud computing service and it is expected that by the end of 2021, cloud data centres will process 94% of workloads. The financial and operational advantages of moving IT infrastructure to specialised cloud providers are clearly compelling. However, with such volumes of private and personal data being stored in cloud computing infrastructures, security concerns have risen.

Expert recommendation from the Swiss Amyloidosis Network (SAN) for systemic AL-amyloidosis.

Systemic amyloidosis is a heterogeneous group of diseases associated with protein misfolding into insoluble beta-sheet rich structures that deposit extracellularly in different organs, eventually compromising their function. There are more than 30 different proteins, known to be amyloidogenic with “light chain” (AL)-amyloidosis being the most common type, followed by transthyretin (ATTR)-, and amyloid protein A (AA)-amyloidosis. Systemic amyloidosis is a rare disease with an incidence of around 10 patients in 1 million inhabitants.

Effect of Triiodothyronine Administration on the Kidney During Haemorrhagic Shock and Resuscitation.

Objective: Apoptosis, measured via caspase activity, can be used to assess renal tissue damage in haemorrhagic shock. We investigated whether Triiodothyronine could attenuate apoptosis and protect against haemorrhagic shock-induced renal injury.

Methods: Haemorrhagic shock was induced in swine until the mean arterial pressure (MAP) was 35-40 mmHg for 40 minutes.

Towards a Multi-Layered Phishing Detection.

Phishing is one of the most common threats that users face while browsing the web. In the current threat landscape, a targeted phishing attack (i.e.

Pharmacologic and Non-Pharmacologic Interventions for HIV-Neuropathy Pain. A Systematic Review and a Meta-Analysis.

Among HIV infection symptoms, sensory neuropathy (HIV-SN) remains a main cause of suffering, with incidence varying from 13-50%. So far, numerous pharmacological and non-pharmacological treatments have been tested, although few evidence-based analgesic options are available. We conducted an up-to-date systematic review and meta-analysis of the literature in order to evaluate the efficacy and safety of pharmacologic and non-pharmacologic treatments for pain control, in patients with HIV neuropathy.

Humanities in Predoctoral Dental Education: A Scoping Review.

Health humanities usually includes such disciplines as philosophy, ethics, history, literature, performing arts, and cultural anthropology. The aims of this scoping review were, first, to search the published literature for references to the humanities in predoctoral dental education and, second, to determine if any research studies found that introducing humanities in dental education improved the overall profile of dental graduates. Literature searches were run in Ovid MEDLINE, Embase, ERIC, CINAHL, and Dentistry and Oral Sciences Source.

A deep learning framework for automatic detection of arbitrarily shaped fiducial markers in intrafraction fluoroscopic images.

Purpose: Real-time image-guided adaptive radiation therapy (IGART) requires accurate marker segmentation to resolve three-dimensional (3D) motion based on two-dimensional (2D) fluoroscopic images. Most common marker segmentation methods require prior knowledge of marker properties to construct a template. If marker properties are not known, an additional learning period is required to build the template which exposes the patient to an additional imaging dose.

[Paradoxical psoriasis induced by anti-TNF - a clinical challenge].

Anti-TNFs have revolutionized the management of numerous chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Although anti-TNF drugs are highly effective, 2-5 % of treated patients develop psoriasis-like skin lesions called paradoxical psoriasis. Paradoxical psoriasis is specific to anti-TNFs and it is, despite clinically resembling classical psoriasis, immunologically distinct.

IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation.

IL-17E (IL-25) is a member of the IL-17 cytokine family involved in the promotion of type 2 immune responses. Recently, IL-17E has been reported to be up-regulated in distinct skin inflammatory diseases such as psoriasis and atopic and contact dermatitis. We assessed the role played by IL-17E in skin inflammation.