Publications by authors named "Myles G Garstang"
Article Synopsis
- A significant portion of intellectual disability cases have unknown genetic causes, but de novo mutations (DNMs) in genes account for up to 40% of them.
- Researchers sequenced genomes from 21 individuals with intellectual disabilities and their parents, discovering that regulatory DNMs are more abundant in fetal brain enhancers compared to adult brain enhancers.
- The study revealed that these regulatory mutations are linked to genes important for brain development, indicating that they significantly contribute to the causes of intellectual disability.
How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of stem cell differentiation or cell programming, or interpret the pathogenicity of noncoding variation. Here, we study histone modifications across thirteen tissues during human organogenesis.
View Article and Find Full Text PDFNoncoding RNAs (ncRNAs) transcribed from active enhancers are known as enhancer RNAs (eRNAs). eRNAs have generally been shown to contribute to transcriptional activation of target genes in cis. In this issue, Tsai et al.
View Article and Find Full Text PDFRetrogenes are formed when an mRNA is reverse-transcribed and reinserted into the genome in a location unrelated to the original locus. If this retrocopy inserts into a transcriptionally favourable locus and is able to carry out its original function, it can, in rare cases, lead to retrogene replacement. This involves the original, often multi-exonic, parental copy being lost whilst the newer single-exon retrogene copy 'replaces' the role of the ancestral parent gene.
View Article and Find Full Text PDFBackground: The ParaHox genes play an integral role in the anterior-posterior (A-P) patterning of the nervous system and gut of most animals. The ParaHox cluster is an ideal system in which to study the evolution and regulation of developmental genes and gene clusters, as it displays similar regulatory phenomena to its sister cluster, the Hox cluster, but offers a much simpler system with only three genes.
Results: Using Ciona intestinalis transgenics, we isolated a regulatory element upstream of Branchiostoma floridae Gsx that drives expression within the central nervous system of Ciona embryos.