Front Endocrinol (Lausanne)
July 2023
Aromatase (Cyp19a1) is the steroidogenic enzyme that converts androgens into bioactive estrogens, and hence is in a pivotal position to mediate reproduction and sexual behavior. In teleosts, there are two aromatase paralogs: that is highly expressed in granulosa and Leydig cells in the gonads with critical function in sexual differentiation of the ovary, and that is highly expressed in radial glial cells in the brain with unknown roles in reproduction. mutant zebrafish lines were used to investigate the importance of the paralogs for spawning behavior and offspring survival and early development.
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