Publications by authors named "Mykolas Mikuciunas"
Background: Gliomas are the most common and aggressive among primary malignant brain tumours with significant inter- and intratumour heterogeneity in histology, molecular profile, and patient outcome. However, molecular targets that could provide reliable diagnostic and prognostic information on this type of cancer are currently unknown. Recent studies show that certain phenotypes of gliomas such as malignancy, resistance to therapy, and relapses are associated with the epigenetic alterations of tumour-specific genes.
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- * The study utilizes quantitative proteomics to explore the submodules and assembly mechanisms of TFIID in human cells, revealing important novel interactions within a specific cytoplasmic submodule comprised of TAF5, TAF6, and TAF9.
- * A significant finding is the role of the chaperonin CCT, which helps guide the assembly of TFIID by assisting nascent TAF5 in its transition to interact with TAF6 and TAF9, indicating a checkpoint mechanism in complex
Aims: NDRG2 (N-myc downstream regulated gene 2) gene is involved in important biological processes: cell differentiation, growth and apoptosis. Several molecular studies have shown NDRG2 as a promising diagnostic marker involved in brain tumor pathology. The aim of the study was to investigate how changes in epigenetic modification and activity of NDRG2 reflect on glioma malignancy and patient outcome.
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