Publications by authors named "Myeong-Seon Kim"

Article Synopsis
  • A nationwide survey in Korea was conducted to investigate the practices of gynecologic oncologists regarding peritonectomy techniques (total vs. selective) for treating advanced ovarian/fallopian tube cancer.
  • Results showed that 98.9% and 93.8% of the oncologists performed selective parietal peritonectomy (SPP) during primary and interval debulking surgeries, while only 4.9% performed total parietal peritonectomy (TPP).
  • Concerns about patient morbidity and unclear benefits of TPP were the main reasons for its low usage, indicating a need for further studies to assess TPP's feasibility before initiating a larger clinical trial.
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  • The report examines the outcomes of advanced ovarian cancer patients who underwent bowel surgery as part of maximal cytoreductive surgery, comparing results between surgeries performed by gynecologic oncologists (GOs) and general surgeons (GSs).
  • It involved 761 patients, revealing that both groups had similar characteristics and complication rates, but GOs had shorter operation times.
  • The study concludes that GOs can safely and feasibly perform bowel surgeries without impacting patient survival, suggesting a need for enhanced training for GOs in this area.
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  • The study investigates the effectiveness of different adjuvant treatments in patients with early-stage endometrial cancer, specifically those classified as 2023 FIGO stage IIC, where aggressive tumor types pose greater risks.
  • Researchers analyzed outcomes from 272 patients, noting that adjuvant treatment did not generally improve recurrence-free survival (RFS) or overall survival (OS), but it showed benefits for specific groups, including those with lymphovascular space invasion (LVSI) and grade 3 endometrioid types.
  • The findings suggest that while adjuvant treatment may not be universally beneficial, it could improve OS for certain high-risk patients, leading to considerations for personalized treatment strategies.
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We investigate silicon oxycarbide nanotubes that incorporate Si, SiC, and silicon oxycarbide phases, which exhibit near zero-strain volume expansion, leading to reduced electrolyte decomposition. The composite effectively accommodates the formation of -LiSi, as validated by TEM analyses and electrochemical tests, thereby proposing a promising solution for Li-ion battery anodes.

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Background: This paper reports on results of a health system strengthening implementation research initiative conducted the Upper East Region of northern Ghana. Transformative interventions to accelerate and strengthen the health delivery were implemented that included empowering community leaders and members to actively participate in health delivery, strengthening the referral systems through the provision of community transport systems, providing basic medical equipment to community clinics, and improving the skills of critical health staff through training.

Methods: A mixed method design was used to evaluate the impact of the interventions.

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Over the past decade, lithium metal has been considered the most attractive anode material for high-energy-density batteries. However, its practical application has been hindered by its high reactivity with organic electrolytes and uncontrolled dendritic growth, resulting in poor Coulombic efficiency and cycle life. In this paper, we propose a design strategy for interface engineering using a conversion-type reaction of metal fluorides to evolve a LiF passivation layer and Li-M alloy.

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We investigated the incidence of reactive thrombocytosis after maximal cytoreductive surgery in advanced epithelial ovarian cancer (EOC) and its role in patient survival. We retrospectively reviewed the electronic medical records of patients who underwent primary cytoreductive surgery for advanced EOC from 1 January 2012 to 31 December 2017. We analyzed the serum platelet counts at various time points from before surgery, during the peri-operative period, and after each cycle of adjuvant chemotherapy.

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Single-port access (SPA) laparoscopic surgery and vaginal natural orifice transluminal endoscopic surgery (vNOTES) have many advantages. The objective of the present study is to compare patient characteristics, operative details, and postoperative outcomes between the two surgical methods. Patients who were planned to undergo vNOTES or SPA laparoscopic surgery between April 2020 and June 2021 were prospectively enrolled.

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Objective: Pulmonary lymphangitic carcinomatosis (PLC) is a rare event of metastatic lung disease in advanced gynecologic malignancy. Nonspecific symptoms of patients and difficulties in detection of PLC often result in a delayed diagnosis. In this study, we evaluated the clinical outcomes of PLC in patients with gynecologic cancer.

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No studies have examined the issue of intraabdominal port-site adhesion following single-port access (SPA) laparoscopic surgeries. The purpose of the present study was to investigate the clinical effects of temperature-sensitive adhesion barrier solution in preventing periumbilical adhesion in SPA laparoscopy. This was a prospective, single-arm study in which patients were given GUARDIX-SGTM after SPA laparoscopic surgery for benign gynecologic diseases.

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Article Synopsis
  • The study investigates how different strains of lactic acid bacteria (LAB) affect the hardening of cheese in Home Meal Replacement (HMR) foods like cheese-rice cakes.
  • Seven cheese samples with varying hardening properties were tested, revealing that certain LAB strains were linked to strong hardening of cheese.
  • Results showed that cheeses dominated by one LAB strain (LC-CD) hardened faster and had lower pH and higher proteolytic activity compared to those dominated by another strain (LM-CD), suggesting that high acid and protease activity contribute to cheese hardening.
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Maximal cytoreductive surgery is an important prognostic factor in advanced epithelial ovarian cancer (EOC). To achieve maximal cytoreductive surgery, en bloc pelvic resection with rectosigmoid colectomy can be an effective surgical strategy. This surgical methodology was first described in 1968 as "radical oophorectomy.

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The enhanced recovery after surgery (ERAS) refers to multimodal interventions to reduce the length of hospital stay and complications at various steps of perioperative care. It was first developed in colorectal surgery and later embraced by other surgical disciplines including gynecologic oncology. The ERAS Society recently published guidelines for gynecologic cancer surgeries to enhance patient recovery.

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To evaluate feasibility and safety of hysterectomy and adnexal procedures by vaginal natural orifice transluminal endoscopic surgery (vNOTES). This is a prospective observational study at a tertiary center and teaching University hospital. We enrolled prospectively 34 patients with benign diseases sequentially.

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Purpose: To investigate the anti-cancer effects of tetraarsenic hexoxide (TAO, AsO) in cervical cancer cell lines and in a series of patient-derived xenograft (PDX) mouse models.

Methods: Human cervical cancer cell lines, including HeLa, SiHa and CaSki, and human umbilical vein endothelial cells (HUVECs), were used to evaluate the anti-cancer activity of TAO. Cellular proliferation, apoptosis, and enzyme-linked immunosorbent assay (ELISA) for matrix metallopeptidase 2 (MMP-2) and 9 (MMP-9) were assessed.

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Objectives: Despite the rise in community health problems in populations living in urban slums, activities of community health nurses are limited in Bangladesh. This study aimed to describe how a nurse-managed health center (NMHC) was developed in Dhaka, Bangladesh.

Design: An exploratory-descriptive research design was used.

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To compare laparoscopic surgery to laparotomy for harvesting para-aortic lymph nodes in presumed stage I-II, high-risk endometrial cancer patients. Patients with histologically proven endometrial cancer, presumed stage I-II with high-risk tumor features who had undergone hysterectomy, bilateral salpingoophorectomy, or pelvic and para-aortic lymphadenectomy by either laparoscopy or laparotomy in Samsung Medical Center from 2005 to 2017 were retrospectively investigated. The primary outcome was para-aortic lymph node count.

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Objective: This study aimed to determine risk factors associated with the failure of uterine artery ligation at its origin following development of the retroperitoneal space (UALr) and evaluated its efficacy in decreasing estimated blood loss (EBL) during single-port total laparoscopic hysterectomy (SP-TLH).

Materials And Methods: This study includes patient data collected prospectively from May 1st, 2013 to establish a registry for single-port surgery. Data for the present study were collected retrospectively from May 1st, 2013 to August 30th, 2016.

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Purpose: We investigated the impact of four types of antihypertensive medications, angiotensin receptor blockers (ARBs), beta blockers (BBs; both selective and non-selective), calcium channel blockers (CCBs), and thiazide diuretics (TDs) on survival outcomes in epithelial ovarian cancer (EOC).

Materials And Methods: A single-institutional retrospective chart review of 878 patients with EOC was performed. Survival was compared according to use of the four antihypertensive medications during primary treatment.

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Article Synopsis
  • This study investigates the prevalence and prognostic effects of genetic mutations and variants of unknown significance (VUS) in Korean patients with epithelial ovarian cancer (EOC), addressing a gap in evidence for Asian populations.
  • Researchers analyzed 313 newly diagnosed EOC patients from 2007 to 2017, finding 28% had mutations and 15% had VUS, but there were no significant survival differences between these groups and those without mutations.
  • While mutations and VUS had similar survival outcomes, mutations were associated with longer progression-free survival (PFS), suggesting that genetic testing may still have important implications for patient management in this population.
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Background: Gynecologic malignancy is one of the leading causes of mortality in female adults worldwide. Comprehensive genomic analysis has revealed a list of molecular aberrations that are essential to tumorigenesis, progression, and metastasis of gynecologic tumors. However, targeting such alterations has frequently led to treatment failures due to underlying genomic complexity and simultaneous activation of various tumor cell survival pathway molecules.

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  • The study aimed to compare the outcomes of laparoendoscopic single-site surgery (LESS) and conventional laparoscopic surgery (CLS) in treating mature cystic teratoma (MCT) of the ovary.
  • A total of 254 patients were analyzed, with most undergoing LESS; factors like operation time, blood loss, and complications showed no significant differences between the two methods.
  • The findings suggest that LESS is a safe and effective alternative to CLS for MCT surgery, offering feasibility and convenience without compromising patient outcomes.
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Purpose: Lymph node metastasis (LNM) is the most significant prognostic factor in cervical cancer that was recently incorporated into the International Federation of Gynecology and Obstetrics (FIGO) staging system. This study was performed to evaluate whether the prognostic significance of LNM differs according to disease status.

Materials And Methods: Patients with FIGO stage IB or higher cervical cancer who had pretreatment computed tomography and/or magnetic resonance imaging studies as well as long-term follow-up were enrolled in this retrospective study.

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Study Objective: MONOFIX, a new absorbable barbed suture device, has a triangular stopper at the end to hold the suture to the tissue without hooking the looped end or knotting. The aim of this study was to compare the biomechanical strength and histologic features of MONOFIX with other barbed suture devices using a porcine model.

Design: Well-designed, controlled trial without randomization.

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Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a history of bloody vaginal discharge for 7 months.

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