Publications by authors named "Myeong-Kyu Sim"
Article Synopsis
- * Research shows that reducing NMU expression in colorectal cancer cells leads to less cell growth and migration, making them more sensitive to radiation, whereas increasing NMU levels makes cells more resistant to radiation and enhances their growth.
- * The study found that NMU affects the activity of crucial proteins YAP and TAZ, which are involved in cell signaling, by altering their movement within the cell and their phosphorylation status, suggesting that NMU may help colorectal cancer cells develop resistance to radiation through the Hippo signaling pathway.
Metformin is one of the most effective therapies for treating type 2 diabetes and has been shown to also attenuate aging and age-related disorders. In this study, we explored the relationship between metformin and DNA damage repair in ionizing radiation (IR)-induced damage of human aortic endothelial cells (HAECs). Metformin treatment suppressed IR-induced senescence phenotypes, such as increased senescent-associated β-galactosidase (SA β-gal) activity and decreased tube formation and proliferation.
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