Publications by authors named "Myeong Jin Son"
Background: Cerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare inherited metabolic disease caused by the mutation in the CYP27A1 gene. Spinal CTX is a rare clinical subgroup of CTX which lacks typical symptoms seen in classical CTX. Here we report a spinal CTX case revealed double mutation of CYP27A1 gene.
View Article and Find Full Text PDFUncontrolled retinal pigment epithelial (RPE) cell proliferation/migration contribute to the pathological tractional membrane development in proliferative vitreoretinopathy. Recent studies reported that microRNA (miR)-124 controls various cellular functions via the direct targeting of small Ras homolog family member G (RHOG). Therefore, we investigated the role of the neuron-specific miR-124 and RHOG in RPE cell proliferation/migration.
View Article and Find Full Text PDFWe aimed to validate a tear MMP-9 in-situ immunoassay (InflammaDry) and to identify factors that could affect results or interpretation. Three factors were examined: sample concentration, volume, and time. Recombinant human (rh) MMP-9 (10 or 20 μl; 0, 12.
View Article and Find Full Text PDFThe tear matrix metalloproteinase-9 (MMP-9) immunoassay (Inflammadry) exhibits variable results in dry eye (DE) patients. We investigated if the tear volume in DE patients affects the results of MMP-9 immunoassay in clinical and in vitro settings. This cross-sectional study enrolled 188 eyes of 188 DE patients.
View Article and Find Full Text PDFPurpose: We aimed to compare the physicochemical properties and in vivo efficacy of commercially available nanoemulsion cyclosporine A (CsA) eyedrops in benzalkonium chloride (BAC)-induced dry eye disease (DED).
Methods: Particle size analysis was performed on conventional 0.05% CsA (Restasis, C-CsA) and two new types of 0.
Article Synopsis
- The study examined the ginsenoside composition and antioxidant properties of hydroponic-cultured ginseng roots (HCR), leaves (HCL), and stems (HCS) using high-performance liquid chromatography.
- It found that HCL and HCS had significantly higher total ginsenoside contents compared to HCR, with Rg1 being the most abundant in leaves while Rb1 was more concentrated in roots.
- The research also demonstrated that HCL exhibited the strongest antioxidant activity and the highest inhibitory effect on tyrosinase activity, suggesting that the entire ginseng plant has beneficial properties as a functional vegetable.