Risk factors for clinical treatment failure regarding Carbapenem-Resistant Enterobacterales in the southwestern United States.

Background: Rates of Carbapenem Resistant Enterobacterales (CRE)-related infections in the United States have continued to rise, leading to significant morbidity and mortality. Klebsiella pneumoniae carbapenemases (KPC) have been the most common carbapenemase in the United States; over time, however, a shift has occurred in some regions.

Methods: A multicenter, retrospective observational study was performed across a large-scale healthcare system of 33 acute care hospitals in the southwestern United States, primarily Arizona.