Electroencephalography source localization analysis in epileptic children during a visual working-memory task.

We localize the sources of brain activity of children with epilepsy based on electroencephalograph (EEG) recordings acquired during a visual discrimination working memory task. For the numerical solution of the inverse problem, with the aid of age-specific MRI scans processed from a publicly available database, we use and compare three regularization numerical methods, namely the standardized low resolution brain electromagnetic tomography (sLORETA), the weighted minimum norm estimation (wMNE) and the dynamic statistical parametric mapping (dSPM). We show that all three methods provide the same spatio-temporal patterns of differences between the groups of epileptic and control children.

Long-term impact of prenatal exposure to chemotherapy on executive functioning: An ERP study.

Objective: This study examines the long-term impact of prenatal exposure to chemotherapy on executive functioning and the contribution of late-prematurity to this effect, using event-related potentials.

Methods: Mothers of the prenatal-exposed children (n = 20) were diagnosed with cancer and received chemotherapeutic treatment during pregnancy. We recruited healthy controls (n = 20) who were matched on a 1:1 ratio regarding prematurity, age and sex.

Risk factors for spontaneous localized intestinal perforation in the preterm infant.

Purpose: The aim of this study was to investigate prenatal and postnatal risk factors for spontaneous intestinal perforation (SIP) in preterm infants.

Material And Methods: Matched case-control study of 62 preterm infants (matching based on gender, gestational age and birth weight) who developed a SIP over a period of 20 years in a single NICU. Univariate and multivariate logistic regression analysis were performed.

Children with well controlled epilepsy possess different spatio-temporal patterns of causal network connectivity during a visual working memory task.

Using spectral Granger causality (GC) we identified distinct spatio-temporal causal connectivity (CC) patterns in groups of control and epileptic children during the execution of a one-back matching visual discrimination working memory task. Differences between control and epileptic groups were determined for both GO and NOGO conditions. The analysis was performed on a set of 19-channel EEG cortical activity signals.

Developmental changes in visuo-spatial working memory in normally developing children: event-related potentials study.

Objective: Working memory (WM) is very important for normal development. The fronto-parietal neuronal network supporting WM has already been well-studied. Less is known about the cortical activity changes during development of WM.

Within-subject variability during spatial working memory in children with ADHD: an event-related potentials study.

Working memory (WM) dysfunction and increased within-subject variability are known issues in attention deficit/hyperactivity disorder (ADHD) patients. Little is known about the electrophysiological characteristics of this variability. We evaluated behavioral and electrophysiological within-subject variability taking developmental aspects into account in a group of ADHD patients.

Impaired spatial working memory in children with well-controlled epilepsy: an event-related potentials study.

Purpose: To find out whether children with epilepsy did show different event-related potentials (ERP) compared to healthy children during performance in a visuo-spatial working memory (WM) task.

Methods: Multichannel ERPs were measured during a visuo-spatial backmatching task. A quantitative analysis technique, based on Statistical Parametric Mapping, was used to analyze the ERP data.

Working memory in children with epilepsy: an event-related potentials study.

Purpose: The aim of this study was to find out whether children with idiopathic epilepsy did show different cortical activation patterns compared to non-epileptic children during performance of a working memory task. To this end event-related potentials (ERPs) were measured during a visual 1-backmatching task. A quantitative analysis technique to analyze the ERP data, without any 'a priori' decisions on 'peak' presence, amplitudes or latencies, is used.

Sleep spindle abnormalities in children with generalized spike-wave discharges.

This study investigated sleep and sleep spindle parameters in children with primary generalized spike-and-wave discharges (untreated primary generalized group, nine patients; treated primary generalized group, six patients) and compared these with an age- and sex-matched nonepileptic control group (n = 47). In the untreated primary generalized group, stage 2 onset was significantly shorter, with less spindles in stage 2. In the last stage 2 period of the night, significantly less fast frequency spindles were observed, indicating abnormal dynamics of sleep architecture.