Multifunctional nanocarriers of FeO@PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery.

Despite medicinal advances, cancer is still a big problem requiring better diagnostic and treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were developed for these unmet needs. This study fabricated novel trifunctional MNPs of FeO@PLA-PEG for drug release, MRI and magnetic fluid hyperthermia.

Applications of Mesoporous Silica-Encapsulated Gold Nanorods Loaded Doxorubicin in Chemo-photothermal Therapy.

We investigate the chemo-photothermal effects of gold nanorods (GNRs) coated using mesoporous silica (mSiO) loading doxorubicin (DOX). When the mesoporous silica layer is embedded by doxorubicin drugs, a significant change in absorption spectra enables to quantify the drug loading. We carried out photothermal experiments on saline and livers of mice having GNRs@mSiO and GNRs@mSiO-DOX.

Nanomelanin Potentially Protects the Spleen from Radiotherapy-Associated Damage and Enhances Immunoactivity in Tumor-Bearing Mice.

Radiotherapy side-effects present serious problems in cancer treatment. Melanin, a natural polymer with low toxicity, is considered as a potential radio-protector; however, its application as an agent against irradiation during cancer treatment has still received little attention. In this study, nanomelanin particles were prepared, characterized and applied in protecting the spleens of tumor-bearing mice irradiated with X-rays.

Role of survivin phosphorylation by aurora B in mitosis.

The chromosomal protein passenger complex, a key mitotic regulator, consists of at least four proteins, INCENP, Aurora B, Survivin and Borealin. Survivin, in contrast to the other members of the chromosomal protein passenger complex (CPC), is mobile at metaphase. This protein is also phosphorylated by Aurora B at Threonine 117.