Two-component system response regulators involved in virulence of Streptococcus pneumoniae TIGR4 in infective endocarditis.

Streptococci resident in the oral cavity have been linked to infective endocarditis (IE). While other viridans streptococci are commonly studied in relation to IE, less research has been focused on Streptococcus pneumoniae. We established for the first time an animal model of S.