Publications by authors named "Mwayi P Kazembe"
Article Synopsis
- The study investigates how filamin A (FLNa), an actin-binding protein, influences the remodeling of the pericellular matrix (PCM) in fibroblasts.
- Mice lacking FLNa in fibroblasts showed increased collagen density but disorganized fibers under stress, indicating FLNa’s role in maintaining proper collagen structure.
- Additionally, FLNa knockdown led to significant changes in collagen phagocytosis and degradation pathways, highlighting its importance in collagen abundance and organization during cellular remodeling processes.
In mechanically loaded tissues such as weight-bearing joints, myocardium, and periodontal ligament, pathophysiological forces can disrupt cell-matrix contacts, which can induce cell death, leading to tissue and organ dysfunction. Protection against force-induced cell death may be mediated by filamin A (FLNa), an actin-binding protein that regulates β1 integrin-mediated cell adhesion. We examined the affect of filamin expression on collagen distribution and cell death in the periodontal ligament, a force-loaded tissue.
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