Publications by authors named "Mvuwo Phophi Tshavhungwe"
Article Synopsis
- Limited research on how rifampicin, a drug for tuberculosis, moves through the body and into the brain in children with tuberculous meningitis (TBM) inspired this analysis of its distribution in cerebrospinal fluid (CSF) and brain tissue.
- The study involved 61 children, aiming to quantify rifampicin levels in plasma, lumbar CSF, ventricular CSF, and brain extracellular fluid using advanced techniques like liquid chromatography and microdialysis.
- Findings revealed that rifampicin concentrations are significantly lower in CSF than in plasma, confirming that the drug penetrates brain tissue and suggesting microdialysis as a useful method for studying drug distribution in TBM.