Publications by authors named "Muyoung Lee"

Mesenchymal stem cells (MSC) are an appealing therapeutic cell type for many diseases. However, patients with poor health or advanced age often have MSCs with poor regenerative properties. A major limiter of MSC therapies is cellular senescence, which is marked by limited proliferation capability, diminished multipotency, and reduced regenerative properties.

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Article Synopsis
  • All eukaryotes originated from a single-celled microbe called the Last Eukaryotic Common Ancestor (LECA), existing 1.5 - 1.8 billion years ago, which shared nearly half of its genes with modern eukaryotes.
  • Researchers identified 10,092 core protein-coding gene families likely present in LECA and utilized over 26,000 mass spectrometry analyses from 31 species to explore how these proteins interact in complex biological systems.
  • By studying these ancient protein interactions, the research revealed new insights into gene-disease relationships in humans, particularly related to bone density and congenital defects, highlighting the importance of understanding LECA's biochemical organization for modern genetics.
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Transcriptional regulation controls cellular functions through interactions between transcription factors (TFs) and their chromosomal targets. However, understanding the fate conversion potential of multiple TFs in an inducible manner remains limited. Here, we introduce iTF-seq as a method for identifying individual TFs that can alter cell fate toward specific lineages at a single-cell level.

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During human pregnancy, extravillous trophoblasts play crucial roles in placental invasion into the maternal decidua and spiral artery remodeling. However, regulatory factors and their action mechanisms modulating human extravillous trophoblast specification have been unknown. By analyzing dynamic changes in transcriptome and enhancer profile during human trophoblast stem cell to extravillous trophoblast differentiation, we define stage-specific regulators, including an early-stage transcription factor, TFAP2C, and multiple late-stage transcription factors.

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In light of the numerous studies identifying post-transcriptional regulators on the surface of the endoplasmic reticulum (ER), we asked whether there are factors that regulate compartment specific mRNA translation in human cells. Using a proteomic survey of spatially regulated polysome interacting proteins, we identified the glycolytic enzyme Pyruvate Kinase M (PKM) as a cytosolic (i.e.

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In this paper, we analyze the dynamics of optical injection in an external cavity based Fabry-Pérot laser diode (ECFP-LD) for wide tunable microwave signal generation. The ECFP-LD is a specially designed FP-LD that has a self-locked single dominant mode. The injected beam power is varied to analyze the dynamics of optical beam injection on the ECFP-LD.

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Global increases in the use of carbapenems have resulted in several strains of Gram-negative bacteria acquiring carbapenem resistance, thereby limiting treatment options. is a common carbapenem-resistant pathogenic bacterium that is widely studied to identify novel antibiotic resistance mechanisms and drug targets. Antibiotic-resistant clinical isolates generally harbor many genetic alterations, and the identification of responsible mutations would provide insights into the molecular mechanisms of antibiotic resistance.

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Bacterial species in the genus infect virtually all crop plants. Although many genes involved in virulence have been identified through molecular and cellular studies, the elucidation of virulence-associated regulatory circuits is still far from complete. Functional gene networks have proven useful in generating hypotheses for genetic factors of biological processes in various species.

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Staphylococcus aureus is a gram-positive bacterium that causes a wide range of infections. Recently, the spread of methicillin-resistant S. aureus (MRSA) strains has seriously reduced antibiotic treatment options.

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Rational: Burns at the site of the return electrode (i.e., grounding pad) are possible effects of electrosurgery.

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Transcription factors (TFs) are major trans-acting factors in transcriptional regulation. Therefore, elucidating TF-target interactions is a key step toward understanding the regulatory circuitry underlying complex traits such as human diseases. We previously published a reference TF-target interaction database for humans-TRRUST (Transcriptional Regulatory Relationships Unraveled by Sentence-based Text mining)-which was constructed using sentence-based text mining, followed by manual curation.

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This paper proposes an enhanced integral imaging system with an electrically controllable image plane to address the issue of the limited depth problem in integral imaging. For implementation of the variable image plane, a varifocal liquid lens array and driving device are adopted instead of an ordinary solid lens array. The position of the central depth plane is varied by adjusting the focal length of the lens array.

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Studies of the interaction between hydrogen and graphene have been increasingly required due to the indispensable modulation of the electronic structure of graphene for device applications and the possibility of using graphene as a hydrogen storage material. Here, we report on the behaviour of molecular hydrogen on graphene using the gate voltage-dependent resistance of single-, bi-, and multi-layer graphene sheets as a function of H₂ gas pressure up to 24 bar from 300 K to 345 K. Upon H₂ exposure, the charge neutrality point shifts toward the negative gate voltage region, indicating n-type doping, and distinct Raman signature changes, increases in the interlayer distance of multi-layer graphene, and a decrease in the d-spacing occur, as determined by TEM.

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