Application of the GheOPS-tool in nursing home residents: acceptance and implementation of pharmacist recommendations.

: The prevalence of potentially inappropriate prescribing (PIP) among nursing home (NH) residents is high. This study aimed to investigate the acceptance and implementation of pharmacist recommendations based on a screening tool for PIP, the Ghent Older People's Prescriptions community Pharmacy Screening (GheOPS)-tool. : Prospective observational study in NH residents (≥ 70 years, using ≥ 5 medications) with a 3-month follow-up period.

Prediction of surgical outcome after aortic valve replacement.

Background: Aortic valve replacement has some major adverse outcomes. For these, the predictors need identification.

Methods: This was a retrospective file study of 1000 consecutive patients who underwent AVR for degenerative aortic valve disease.

A thousand pericardial valves in aortic position: risk factors for postoperative acute renal function impairment in elderly.

Aim: Postoperative renal dysfunction after aortic valve replacement is a serious complication. To minimize its occurrence, risk factors have to be identified, and if possible eliminated.

Methods: Of 1000 consecutive patients, who underwent AVR, a file study was performed chi(2)nd logistic regression analysis were performed to study the effect of 24 preoperative, 7 peroperative and 7 postoperative factors on the occurrence of 30-day postoperative worsening of renal function.

One thousand Carpentier-Edwards pericardial valves in the aortic position: what has changed in the past 20 years, and what are the effects on hospital complications?

Background And Aim Of The Study: Over the past 20 years, both the typical age and co-morbidity of patients referred for aortic valve replacement (AVR) have increased. In order to assess the effect of these changes on hospital complications, an evaluation was conducted of patient characteristics within this time period.

Methods: This retrospective study included 1,000 consecutive patients who underwent AVR with a pericardial valve.

Risk factors for congestive heart failure after aortic valve replacement with a Carpentier-Edwards pericardial prosthesis in the elderly.

Background And Aim Of The Study: Congestive heart failure (CHF) after aortic valve replacement (AVR) is an important cause of morbidity. The study aim was to identify preoperative risk factors for CHF.

Methods: A total of 500 consecutive patients (271 males, 229 females; median age 73 years; range: 71-77 years) was investigated retrospectively.

Timing of aortic valve replacement in elderly patients with symptomatic aortic valve disease using outpatient clinical parameters.

Objective: To determine by how far worsening outpatient clinical parameters can affect outcome after aortic valve replacement, in patients with preserved left ventricular function and symptomatic aortic valve disease.

Patients And Methods: Five hundred patients with aortic valve disease underwent aortic valve replacement using a bioprosthesis. In 348 patients, another procedure was added.

Risk factors and survival after aortic valve replacement in octogenarians.

Background And Aim Of The Study: The study aim was to determine if aortic valve replacement in octogenarians is still rewarding.

Methods: Between 1986 and 2000, 500 patients received a Carpentier-Edwards pericardial valve in the aortic position. Of these patients, 348 also underwent coronary artery bypass grafting (CABG).

Effect of prior malignancy on survival after cardiac surgery.

Background: The number of patients with a previously treated tumor, needing cardiac surgery is increasing. Whether this operation in these patients is justified is determined by the long-term outcome.

Methods: Of 8620 patients referred for cardiac surgery, 205 had a documented malignant tumor.

Thromboembolic events after aortic valve replacement in elderly patients with a Carpentier-Edwards Perimount pericardial bioprosthesis.

Objectives: Thromboembolic events after aortic valve replacement with a bioprosthesis were the most frequently occurring complications in elderly patients. Whether this was valve related or dependent on other factors needed further exploration.

Methods: Five hundred patients with a median age of 73 years were followed retrospectively after aortic valve replacement with a pericardial prosthesis for occurrence of thromboembolism.

Role of age, gender and association of CABG on long-term results after aortic valve replacement with a Carpentier-Edwards bioprosthesis in the elderly.

Aim: The problem of postoperative sudden death and the effect of age, gender and association of coronary artery bypass grafting were studied after implantation of a bioprosthetic valve in aortic position.

Design: retrospective investigation during 13 year.

Setting: general hospital.

Determinants of survival after aortic valve replacement as treatment for symptomatic aortic valve disease in the elderly.

Background And Aim Of The Study: The effect of concurrent disease and cardiac comorbidity on survival after bioprosthetic valve replacement in elderly patients was assessed retrospectively. Risk factors were categorized as general, non-cardiac (age, diabetes, previously treated carcinoma) and cardiac (LVEF, three-vessel disease, previous CABG or valve replacement, and endocarditis).

Methods: A total of 400 elderly patients (median age 73 years; range: 71-76 years) was studied.

High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery.

The design of effective gene delivery systems for gene transfer in primary human blood cells is important both for fundamental hematopoiesis research and for cancer gene therapy strategies. Here, we evaluated electroporation as a nonviral means for transfection of activated human T lymphocytes and adult bone marrow (BM) CD34+ cells. We describe optimal culture and electroporation parameters for efficient gene delivery in prestimulated T lymphocytes (16.

Developmentally regulated responsiveness to transforming growth factor-beta is correlated with functional differences between human adult and fetal primitive hematopoietic progenitor cells.

Important functional differences exist between primitive CD34++ CD38- hematopoietic progenitor cells derived from human fetal liver (FL) and adult bone marrow (ABM). FL progenitors are known to have higher proliferative capacities and lower cytokine requirements than their ABM counterparts. In this study, we isolated FL and ABM CD34++ CD38- cells and used a two-stage culture system to investigate the effects of transforming growth factor-beta (TGF-beta) and blocking anti-TGF-beta antibodies (anti-TGF-beta) on these cells.

Clinical evaluation of the oxygenation capacity and controllability of 15 commercially available membrane oxygenators during alpha-stat regulated hypothermic cardiopulmonary bypass.

Oxygenation performance was tested in 15 membrane oxygenators by calculating the resistance for oxygenation (R) and the calculation of oxygen transferred versus FiO2. The clinical data reveal that the SARNS Turbo 440 (36.7-51.

Priming solutions for cardiopulmonary bypass: comparison of three colloids.

The present study was designed to compare the differences in the clinical effects of three colloidal solutions, albumin, urea-linked gelatin, and succinyl-linked gelatin, when used as priming fluids for cardiopulmonary bypass (CPB) under alpha-stat conditions. A consecutive series of 105 patients scheduled for cardiac surgery were randomized into three identically managed groups, except for the CPB prime. Variables relating to acid-base status, oncotic activity, metabolism, coagulation, and postoperative evaluation were measured.

Predictive value of coagulation testing in cardiopulmonary bypass surgery.

Severe postoperative bleeding in cardiopulmonary bypass surgery is still a major problem. One hundred and seven patients undergoing uncomplicated coronary artery bypass grafting (CABG) were studied. Two groups were formed according to the patients' 24 hours postoperative mediastinal blood loss.

The cerebro-vascular problem in coronary by-pass surgery.

In 99 of 2250 consecutive C.B.P.

alpha-Adrenergic control of oxygen delivery to myocardium during exercise in conscious dogs.

alpha-Adrenergic control of the oxygen delivery to the myocardium during exercise was investigated in eight conscious dogs instrumented for chronic measurements of coronary blood flow, left ventricular (LV) pressure, aortic blood pressure, and heart rate and sampling of arterial and coronary sinus blood. After alpha-adrenergic receptor blockade a standard exercise load elicited a significantly greater increase in heart rate, rate of change of LV pressure (LV dP/dt), LV dP/dt/P, and coronary blood flow than was elicited in the unblocked state. In contrast to the response pattern during control exercise, there was no significant change in coronary sinus oxygen tension (PO2), myocardial arteriovenous oxygen difference, and myocardial oxygen delivery-to-oxygen consumption ratio.

Alteration in myocardial oxygen balance during exercise after beta-adrenergic blockade in dogs.

The effects of beta-adrenergic blockade upon myocardial blood flow and oxygen balance during exercise were evaluated in eight conscious dogs, instrumented for chronic measurements of coronary blood flow, left ventricular pressure, aortic blood pressure, heart rate, and sampling of arterial and coronary sinus venous blood. The administration of propranolol (1.5 mg/kg iv) produced a decrease in heart rate, peak left ventricular (LV) dP/dt, LV (dP/dt/P, and an increase in LV end-diastolic pressure during exercise.