Publications by authors named "Muxin Chen"

Increasing evidence demonstrates that helminth and its components can ameliorate ulcerative colitis. Clonorchis sinensis (C. sinensis) is a kind of helminth that dwells in the bile ducts for many years, but the roles and underlying mechanisms of C.

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Objectives: To estimate the global burden of malaria and neglected tropical diseases (NTDs) in children and adolescents aged 0-19 years and to analyse trends to inform public health and policy decisions.

Design: Population-based, cross-sectional study.

Setting: Global analysis across 204 countries and territories.

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Background: The emergence of dengue fever has prompted significant public health responses, highlighting the need for a comprehensive understanding of One Health in addressing vector-borne diseases. China's experience in dengue control and prevention programs offers valuable insights into the successful integration of multidisciplinary strategies.

Aims: The review aims to: (1) systematically analyze lessons from China's dengue control and prevention programs, focusing on the integration of these efforts with the One Health approach; (2) underscore the reasons of optimizing the dengue control and prevention program; (3) highlight the alignment of China's dengue control strategies with the One Health framework; (4) contribute to global efforts in combating dengue, providing scientific evidence and strategic recommendations for other regions facing similar challenges.

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  • Upper respiratory infections (URIs) are prevalent worldwide, making it essential for governments to understanding their impact for effective healthcare planning and resource allocation.
  • An analysis of the GBD 2021 data showed a significant decline in various URI metrics (incidence, prevalence, mortality, and disability) from 1990 to 2021, particularly affecting the elderly and young children.
  • Future projections indicate a rise in URI incidence and prevalence from 2022 to 2050, while mortality rates are expected to decline, highlighting ongoing public health challenges, especially related to factors like low birth weight.
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  • A study was conducted to validate the Perioperative Frailty Index (FI-32) for elderly patients undergoing surgery in China, focusing on how preoperative frailty affects postoperative outcomes and complications compared to other tools like the FRAIL scale and modified Frailty Index (mFI-11).
  • The research involved 335 patients aged 60 and older, assessing their frailty levels and tracking outcomes such as readmission and mortality within 30 and 90 days post-surgery.
  • Results showed a frailty prevalence of 16.4% using FI-32, and after controlling for various factors, the study aimed to understand the relationship between frailty and complications in this patient population.
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Background: Cognitive frailty (CF) is characterized by the coexistence of physical frailty and cognitive impairment, and it is associated with adverse health outcomes. Older adults are particularly vulnerable to CF due to factors such as age-related brain changes and the presence of comorbidities.

Objective: To investigate the effect of preoperative CF on postoperative complications in older patients.

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  • A 30-year-old pregnant woman in Shandong Province, China, was diagnosed with a persistent high fever, and high-throughput sequencing identified the presence of the parasite Trypanosoma dionisii in her blood.
  • The patient showed symptoms like fever and respiratory issues but made a full recovery without long-term effects; genetic analysis revealed her infection was closely related to T. dionisii found in local bats.
  • This case highlights T. dionisii as a potential zoonotic pathogen, emphasizing the risk of its transmission from wildlife, particularly rodents and bats, to humans.
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  • * Utilizing data from the Global Burden of Disease Study 2021, the research analyzed trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for various forms of HIV-related TB from 1990 to 2021.
  • * In 2021, the rates showed that HIV-DS-TB had the highest incidence and mortality rates compared to HIV-MDR-TB and HIV-XDR-TB, with significant increases in the incidence and mortality of multi-drug resistant and extensively drug-resistant forms over the study
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The intracellular parasite Babesia microti is among the most significant species causing human babesiosis and is an emerging threat to human health worldwide. Unravelling the pathogenic molecular mechanisms of babesiosis is crucial in developing new diagnostic and preventive methods. This study assessed how priming with B.

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Biochar-derived dissolved organic matter (BDOM) has the potential to influence the environmental application of biochar and the behavior of heavy metals. In this study, the binding properties of BDOM derived from livestock manure biochar at different pyrolysis temperatures with Cu(II) were investigated based on a multi-analytical approach. The results showed that the DOC concentration, aromatics, and humification degree of BDOM were higher in the process of low pyrolysis of biochar.

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The occurrence and transformation of microplastics (MPs) in environment has attracted considerable attention. However, the release characteristics of MP-derived dissolved organic matter (MP-DOM) under oxidation conditions and the effect of DOM on subsequent chlorination disinfection by-product (DBP) still lacks relevant information. This study focused on the conversion of polystyrene microplastics (PSMPs) in the advanced oxidation of ultraviolet-activated sodium percarbonate (UV/SPC-AOP) and the release characteristics of MP-DOM.

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  • Previous studies suggested a link between inflammatory cytokines and tuberculosis (TB), but this research aimed to clarify that relationship using Mendelian randomization analyses with data from genetic studies and TB cases.
  • The analysis found a positive causal relationship between interleukin-7 levels and TB risk, while negative associations were identified for several factors, including macrophage inflammatory protein 1 alpha and interleukins 2 and 2 receptor alpha.
  • This study enhances our understanding of TB mechanisms and may lead to new ways to identify potential treatments or interventions.
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Background: Blastocystis hominis (Bh) is zoonotic parasitic pathogen with a high prevalent globally, causing opportunistic infections and diarrhea disease. Human immunodeficiency virus (HIV) infection disrupts the immune system by depleting CD4 T lymphocyte (CD4 T) cell counts, thereby increasing Bh infection risk among persons living with HIV (PLWH). However, the precise association between Bh infection risk and HIV-related biological markers and treatment processes remains poorly understood.

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Surgical Site Infection (SSI) is one of the common postoperative complications after gastric cancer surgery. Previous studies have explored the risk factors (such as age, diabetes, anaemia and ASA score) for SSI in patients with gastric cancer. However, there are large differences in the research results, and the correlation coefficients of different research results are quite different.

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Introduction: is the dominant species responsible for human babesiosis, which is associated with severe hemolytic anemia and splenomegaly because it infects mammalian erythrocytes. The actual prevalence of is thought to have been substantially underestimated.

Methods: In this study, Bagg's albino/c (BALB/c) mice were intraperitoneally injected with -infected erythrocytes, and parasitemia was subsequently measured by calculating the proportion of infected erythrocytes.

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Background: There is a raising concern of a higher infectious Omicron BA.2 variant and the latest BA.4, BA.

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Microplastic-derived dissolved organic matter (MP-DOM) is ubiquitous in water environment and exhibits photosensitivity. However, little is known about the effects of MP-DOM on the photodegradation of organic micropollutants in natural water. In this study, we investigated the effect of MP-DOM derived from two typical plastics, i.

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The coronavirus disease 2019 (COVID-19) epidemic in China had been effectively controlled for several months, but as the ambient temperature dropped, large gathering-initiated epidemics occurred in northern China, including Hebei, Liaoning, and Jilin provinces. A sudden epidemic emerged in Wangkui County, Suihua City, Heilongjiang Province, on January 9, 2021. An asymptomatically-infected resident of Harbin City returned from Suihua and triggered a large-scale outbreak in the Zhengda Food Processing Company in Harbin, Heilongjiang.

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Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, which has caused unprecedented damage to human health and life. The present study aimed to carry out and discover asymptomatic infected individuals in Shenzhen, China. The data will provide the control measures to stop COVID-19 prevalence.

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constitutes a major etiologic agent of eosinophilic meningoencephalitis. The detection methods for angiostrongyliasis mainly depend on morphology or immunology. A firmer diagnosis could be reached by directly detecting the parasite in the cerebrospinal fluid or through laboratory assays that are specific for -induced antibodies or the parasite's DNA.

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Unlike microglia and NG2 glia, astrocytes are incapable of migrating to sites of injury in the posttraumatic cerebral cortex, instead relying on proliferation to replenish their numbers and distribution in the affected region. However, neither the spectrum of their proliferative repertoire nor their postinjury distribution has been examined in vivo. Using a combination of different thymidine analogs and clonal analysis in a model of repetitive traumatic brain injury, we show for the first time that astrocytes that are quiescent following an initial injury can be coerced to proliferate after a repeated insult in the cerebral cortex grey matter.

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Fascioliasis has emerged as a significant public health problem among ruminants and humans. Human fascioliasis is a neglected food-borne parasitic disease, which has emerged or reemerged in more than 60 countries worldwide. In China, the first case of human fascioliasis was reported in 1921 in Fujian Province.

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