Publications by authors named "Mutsumi Shidahara"
Article Synopsis
- - The study focuses on how trehalose, a nonreducing disaccharide, impacts skin barrier function and addresses skin problems like atopic dermatitis (AD) by regulating skin-barrier-related genes in keratinocytes.
- - It found that trehalose can counteract the negative effects of Th2 cytokines (IL-4/IL-13), which typically impair skin barrier function by downregulating important proteins and antimicrobial peptides.
- - Trehalose achieves this by inhibiting IL-33 expression, activating Nrf2 for antioxidant defense, and preventing the activation of signaling pathways that worsen skin barrier dysfunction, suggesting its potential as a therapeutic agent for AD.
Simple methods, such as the line spread test (LST), are often used to evaluate thickened liquids in clinical settings. Although it is desirable for these simple methods to be rapid, even the LST requires approximately 1 min to complete the evaluation. Herein, we aimed to shorten this time by developing a new simple instrument for evaluating thickened liquids considering the fluid engineering perspective with improved funnel design and evaluation methods.
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