Publications by authors named "Mutsumi Iwamoto"
Article Synopsis
- - The study aimed to compare the safety and effectiveness of transluminal foam sclerotherapy combined with endovenous laser ablation (EVLA) against EVLA alone for treating small saphenous vein incompetence, focusing on changes in the venous clinical severity score (VCSS) over one year.
- - Researchers conducted the study by using a sheath for foam sclerotherapy during the EVLA procedure, assessing various outcomes such as VCSS changes, reflux recurrence, and complications at multiple time points after treatment.
- - Results indicated that while the change in VCSS wasn't significantly impactful, the combination treatment (TLFS + EVLA) led to lower rates of residual or recurrent reflux compared to EVLA alone, suggesting TLFS
Article Synopsis
- The study introduced a new method called tip detection (TD) combined with a special wire (CP12ST) to enhance the effectiveness of treating chronic total occlusion (CTO) in coronary procedures.
- Researchers compared the success rates and procedural times of the TD method with an existing technique (Stingray) using a different wire (CP20) in 54 total cases.
- The findings showed that the TD method led to a significantly higher success rate (100% vs 67%) and shorter procedural times (145 minutes vs 185 minutes), with few complications in both groups.
Article Synopsis
- The study analyzed how different ultrasound frequency settings affect the accuracy of measuring global longitudinal strain (GLS) using 2D speckle tracking echocardiography (2DSTE) in 162 patients.
- Three frequency presets were used: high resolution (HRES), general (HGEN), and penetration mode (HPEN), leading to significant variations in the GLS measurements among the different settings (p < 0.0001).
- Overall, while frequency settings influenced GLS results slightly, the measurements remained reliable across various conditions, suggesting that GLS can be effectively assessed regardless of the ultrasound frequency used.
Article Synopsis
- Researchers developed the GUIDE PLUS® 5Fr catheter and the GP-Lock method to enhance backup support during PCI (percutaneous coronary intervention) procedures.
- The GP-Lock method demonstrated the highest backup force of 293.7 gf compared to 270.4 gf for the KIWAMI-Lock method, and other conventional methods, highlighting its effectiveness.
- GP-Lock also reduced preparation time significantly (5 minutes) compared to KIWAMI-Lock (11 minutes), making it a more efficient option for complex PCI situations.
Article Synopsis
- When trying to remove a trapped guidewire, the core wire may break, causing the spring wire to stretch while the guidewire is still stuck.
- This situation can complicate the removal process and lead to complications.
- The problem was successfully fixed using rotational atherectomy, which allowed for the spring wire to be cut at the intended spot, even if the core wire had fractured.
Article Synopsis
- Global longitudinal strain (GLS) and tissue mitral annular displacement (TMAD) are both measures of heart function that can predict outcomes after a heart attack (myocardial infarction, MI).
- In a study of 246 MI patients, TMAD showed a strong correlation with GLS and the left ventricular ejection fraction (LVEF), while being less affected by image quality.
- Both TMAD and GLS were effective in predicting long-term mortality, with TMAD offering a straightforward alternate method for assessing patient risk after MI.
Creation of a distal re-entry site is widely performed to treat subintimal hematoma. However, this method has a risk of further vessel damage. The present aspiration technique after sealing the entry site by stenting is more promising because the hematoma can be reduced without additional vessel damage.
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- The AnteOwl WR-based technique is designed specifically for treating chronic total occlusions in blood vessels.
- This new method utilizes a tip detection technique for better navigation during the procedure.
- It has proven to be more effective than the older Navifocus WR method for treating these challenging lesions.
An 84-year-old man was admitted to the authors' hospital for the treatment of intermittent claudication. Angiography revealed an exophytic calcified nodules in the distal superficial femoral artery. Angioscopy also revealed abundant exophytic atherosclerotic calcification.
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- The study aimed to evaluate the safety and effectiveness of two methods of foam sclerotherapy combined with endovenous laser ablation (EVLA) in patients with chronic venous disease and great saphenous vein (GSV) reflux.
- A total of 467 patients with GSV reflux were screened and randomly assigned to receive either transluminal injection foam sclerotherapy (TLFS) or ultrasound-guided foam sclerotherapy (UGFS) alongside EVLA, with the exclusion of those with certain health conditions.
- Results after one year showed significant improvement in the venous clinical severity score (VCSS) for the TLFS group compared to the UGFS group, indicating TLFS is a more effective option with
Objectives: This study assessed the efficacy of the tip detection method during intravascular ultrasound (IVUS)-based 3-dimensional (3D) wiring with a new chronic total occlusion (CTO)-specific IVUS system (AnteOwl IVUS [AO-IVUS]) for CTO percutaneous coronary intervention (PCI).
Background: The study developed angiography-based 3D wiring for CTO-PCI. Previously, the authors produced a short-tip CTO-specific IVUS system (Navifocus WR IVUS [Navi-IVUS]), which has been upgraded into the AO-IVUS system by adding a pullback transducer system for IVUS-based 3D wiring.
Objectives: This study sought to compare the procedural outcomes of percutaneous coronary intervention for chronic total occlusion between the periods before and after introduction of 3-dimensional (3D) wiring.
Background: Previously, we reported a 3D wiring method by which the operator can construct real-time mental 3D images from 2 perpendicular angles of X-ray system monitor during percutaneous coronary intervention for chronic total occlusion.
Methods: A total of 137 chronic total occlusion lesions that could not be passed by tapered soft wires in our hospital between 2012 and 2017 were retrospectively enrolled in the study.
Background: Early initiation of EPA treatment in combination with a statin within 24h after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) reduces inflammation and ventricular arrhythmia compared with statin monotherapy; however, the impact of early initiation of EPA treatment on cardiovascular events is unclear. We determined whether early eicosapentaenoic acid (EPA) treatment in patients with acute coronary syndrome (ACS) reduces adverse cardiovascular events.
Methods: This prospective, open-label, blind end point-randomized trial consisted of 241 patients with ACS.
Objective: We examined whether early loading of eicosapentaenoic acid (EPA) reduces clinical adverse events by 1 month, accompanied by a decrease in C-reactive protein (CRP) values in patients with acute myocardial infarction (MI).
Background: Acute MI triggers an inflammatory reaction, which plays an important role in myocardial injury. EPA could attenuate the inflammatory response.
Objective: Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine that is associated with insulin resistance in animals. To extend these observations to humans, we investigated the association of serum SFRP5 levels in subjects with and without coronary artery disease (CAD).
Methods: Subjects (n=185, 68±11 years, 79% male) suspected of having CAD were enrolled in the study and were divided into two groups, CAD and non-CAD subjects, according to the results of their coronary angiographies.
The association between circulating adipocyte fatty acid-binding protein (A-FABP) levels and coronary artery disease (CAD) is reported. We assessed whether plasma A-FABP levels are associated with angiographic coronary lesion morphology in patients with stable CAD. Serum A-FABP levels were analyzed in 115 patients with stable CAD (mean age 69 ± 10 years; 80 % men).
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) is associated with cardiovascular events. Adipocyte fatty acid-binding protein (A-FABP) plays an important role in atherosclerosis. We investigated whether plasma A-FABP is involved in renal function in patients with stable angina pectoris.
View Article and Find Full Text PDFBackground: Adipocyte fatty acid-binding protein (A-FABP) has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently associated with the presence of coronary artery disease (CAD).
Methods: Two hundred eleven consecutive male patients (mean age: 66 years, range: 33-87 years) were enrolled from inpatients who underwent coronary angiography.
Connective tissue growth factor (CTGF) is a secreted protein that regulates fibrosis. We hypothesized that CTGF is induced in a pressure-overloaded (PO) heart and that blocking the angiotensin II type 1 receptor would reduce CTGF expression. Accordingly, we administered olmesartan and compared its effects with other antihypertensive drugs in a PO heart.
View Article and Find Full Text PDFObjectives: We examined the serum levels of interferon-gamma-inducible protein 10 (IP-10), an inflammation-induced chemokine, in acute myocardial infarction (AMI).
Design And Methods: The subjects were 33 AMI patients, 20 stable angina pectoris patients (AP) and 20 normal subjects. In AMI patients, blood samples were collected before percutaneous coronary intervention (PCI) and on days 3, 7 and 28.