Synthesis of Ursolic Acid-based Hybrids: Antibacterial, Cytotoxicity Studies, Physicochemical and Pharmacokinetic Properties.

Background: There is a critical need for the discovery of novel and effective antibacterial or anticancer molecules.

Objectives: Amine-linked ursolic acid-based hybrid compounds were prepared in good yields in the range of 60-68%.

Methods: Their molecular structures were successfully confirmed using different spectroscopic methods including H/C NMR, UHPLC-HRMS and FTIR spectroscopy.

Synthesis of Ester-Linked Ursolic Acid-Based Hybrid Compounds: Potential Antibacterial and Anticancer Agents.

The molecular hybridization of two or more drugs into a single molecule is an effective drug design approach to reduce pill burden and improve patient treatment adherence. Ursolic acid-based hybrid compounds were synthesized and characterized followed by molecular docking studies. In vitro studies against various bacterial strains and human cancer cells (MDA-MB-231, HeLa, and MCF-7) were performed.

New isoflavan from .

Chemical investigation of the root wood of led to the isolation of one previously undescribed isoflavan (33-7-hydroxy-2'-methoxy-[3″-hydroxy-2″,2″-dimethylpyrano (3',4')] isoflavan , together with eleven known compounds . The structure of compound was elucidated on the basis of extensive spectroscopic and spectrometric analyses (1 D and 2 D-NMR and APCI-HRMS), with absolute configurations established by comparison of experimental and DFT calculated ECD data. The assignment of the absolute configurations of C-3 and C-3″ of compounds and , respectively, were reported for the first time.

Characterization of an Exopolymeric Flocculant Produced by a sp.

We evaluated the bioflocculant production potential of an Actinobacteria, which was isolated from a freshwater environment in the Eastern Cape province of South Africa. 16S rDNA nucleotide sequencing analyses revealed that the actinobacteria belongs to the genus, and the sequences were deposited in the GenBank as sp. UFH, with accession number HQ537131.