Publications by authors named "Mutiara Mutiara"
Background: Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention. Previous chemoprevention randomised controlled trials (RCTs) did not individually show benefit of HCQ against COVID-19 and, although meta-analysis did suggest clinical benefit, guidelines recommend against its use.
Methods And Findings: Healthy adult participants from the healthcare setting, and later from the community, were enrolled in 26 centres in 11 countries to a double-blind, placebo-controlled, randomised trial of COVID-19 chemoprevention.
Characteristics and clinical outcomes of patients with pre-delta, delta and omicron SARS-CoV-2 infection in Indonesia (2020-2023): a multicentre prospective cohort study.
Lancet Reg Health Southeast Asia
March 2024
Article Synopsis
- A study in southeast Asia analyzed the impact of SARS-CoV-2 variants and inactivated vaccines on COVID-19 severity and mortality from September 2020 to January 2023, covering pre-delta, delta, and omicron phases.
- Findings revealed that while delta variant infections had a higher rate of severe cases (50.1%) and mortality (24.4%), the omicron variant showed significantly lower rates (15.2% for severe disease and 9.6% for mortality).
- Vaccination significantly reduced the odds of severe disease (by 89% for delta and 98% for omicron), and vaccinated individuals experienced a lower likelihood of death compared to unvaccinated individuals (51% overall reduction
The Delta variant of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) dominated the coronavirus disease 2019 (COVID-19) pandemic in 2021. Here we report the Delta variant among pediatric cases in North Sumatra, Indonesia, from June to July 2021. Whole-genome sequencing (WGS) from 18 new COVID-19 pediatric patients showed that six were B.
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