Publications by authors named "Mutian Zheng"
Article Synopsis
- Prior antibiotic exposure, particularly to carbapenems and vancomycin, is linked to a higher incidence of Ventilator-Associated Pneumonia (VAP) in children on mechanical ventilation, with VAP affecting about 21.94% of the studied population.
- The VAP group demonstrated significantly longer hospital and PICU stays, as well as increased mechanical ventilation duration compared to the non-VAP group, along with higher mortality rates (36.07% vs. 21.82%).
- Factors such as prolonged carbapenem use (≥7 days), repeated intubations, and tracheostomy emerge as independent risk factors for VAP occurrence, highlighting the need for further research on antibiotic regimes.
Traumatic brain injury (TBI)-induced neuroinflammation is closely associated with poor outcomes and high mortality in affected patients, with unmet needs for effective clinical interventions. A series of causal and disseminating factors have been identified to cause TBI-induced neuroinflammation. Among these are cellular microvesicles released from injured cerebral cells, endothelial cells, and platelets.
View Article and Find Full Text PDFNeuroinflammation and the NACHT, LRR, and PYD domains-containing protein 3 inflammasome play crucial roles in secondary tissue damage following an initial insult in patients with traumatic brain injury (TBI). Maraviroc, a C-C chemokine receptor type 5 antagonist, has been viewed as a new therapeutic strategy for many neuroinflammatory diseases. We studied the effect of maraviroc on TBI-induced neuroinflammation.
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