Publications by authors named "Mutiah Mutmainnah"
Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study.
J Pathol Transl Med
November 2024
Article Synopsis
- The study investigates how consistent Indonesian pathologists are in diagnosing thyroid tumors, focusing on identifying nuclear features and invasion characteristics of the tumors.* -
- Fifteen pathologists independently ranked 14 digital slides, revealing that initial agreement on key features was low, but training improved these scores significantly.* -
- The findings highlight the need for continued education and collaboration among pathologists to enhance diagnostic accuracy in thyroid neoplasms.*
Objective: Twenty percent of all classical Hodgkin lymphoma (CHL) cases relapse and recur, especially in advanced stages with a high International Prognostic Score (IPS). Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a regulatory molecule that can inhibit the immune response and is related to tumor aggressiveness. This study aimed to determine the relationship between CTLA-4 expression in advanced-stage CHL and IPS, identifying it as a potential therapy target.
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- The study classifies papillary thyroid carcinoma (PTC) into two types: RAS-like (indolent) and BRAF-like (aggressive) based on specific gene mutations.
- It investigates differences in clinicopathology and protein expression (pERK1/2) between these two PTC types using a sample of 222 cases, applying statistical models to predict mutations.
- Key findings suggest specific factors (like nuclear score and histology subtype) can independently predict V600E mutations, with distinct predictive models indicating biological behavior differences between BRAF-like and RAS-like tumors.
Introduction: V600E and mutations are the most common gene mutations in papillary thyroid carcinoma (PTC) that may be correlated with its biological behavior. There are still limited data about V600E and mutations in Indonesia. This study aims to determine the prevalence of V600E and mutations, and their association with clinicopathologic characteristics.
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