Publications by authors named "Muthusamy S Kumar"

Residual blood specimens collected at health facilities may be a source of samples for serosurveys of adults, a population often neglected in community-based serosurveys. Anonymized residual blood specimens were collected from individuals 15 - 49 years of age attending two sub-district hospitals in Palghar District, Maharashtra, from November 2018 to March 2019. Specimens also were collected from women 15 - 49 years of age enrolled in a cross-sectional, community-based serosurvey representative at the district level that was conducted 2 - 7 months after the residual specimen collection.

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Article Synopsis
  • Residual blood specimens offer a cost-effective way to track seroprevalence changes compared to traditional household surveys, as shown in a study in India focused on measles-rubella vaccinations.
  • A cross-sectional survey in Kanpur Nagar and Palghar found significant increases in rubella seroprevalence post-immunization, though measles trends were inconsistent between facility and community samples.
  • Younger children in public facilities initially had lower rubella seroprevalence than those in private hospitals, but this gap disappeared after the vaccination campaign, highlighting the importance of residual specimens for public health monitoring.
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We conducted a systematic review of analytical epidemiological studies to assess the association between ChAdOx1-S vaccination and thromboembolic, thrombocytopenic, and hemorrhagic events. We searched Medline, Embase, Google Scholar, WHO-COVID-19 database, and medRxiv for studies evaluating the association between ChAdOx1-S and vascular events. Primary outcomes of interest were cerebral venous sinus thrombosis, peripheral venous thrombosis (PVT), and thrombocytopenia.

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Background: Indian subcontinent being an important region in the fight to eliminate cholera needs better cholera surveillance. Current methods miss most infections, skewing disease burden estimates. Triangulating serosurvey data, clinical cases, and risk factors could reveal India's true cholera risk.

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Background: In alignment with the Measles and Rubella (MR) Strategic Elimination plan, India conducted a mass measles and rubella vaccination campaign across the country between 2017 and 2020 to provide a dose of MR containing vaccine to all children aged 9 months to 15 years. We estimated campaign vaccination coverage in five districts in India and assessed campaign awareness and factors associated with vaccination during the campaign to better understand reasons for not receiving the dose.

Methods And Findings: Community-based cross-sectional serosurveys were conducted in five districts of India among children aged 9 months to 15 years after the vaccination campaign.

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This study investigates the influence of surface nitridation of Ta metal foil substrates on the growth of GaN nanorods using the laser molecular beam epitaxy (LMBE) technique and the field emission characteristics of the grown GaN nanorod ensemble. Surface morphology examinations underscore the pivotal role of Ta foil nitridation in shaping the dimensions and densities of GaN nanorods. Bare Ta foil fosters the formation of high-density, vertically self-aligned GaN nanorods at a growth temperature of 700 °C.

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Introduction: India launched the COVID-19 vaccination drive on 16th January 2021 by vaccinating the adult population above 18 years of age. This was followed by the introduction of an additional precaution dose. As on 18th October 2022, 1,02,66,96,808 (1.

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  • A study was conducted in India to investigate sudden unexplained deaths among healthy young adults (ages 18-45) possibly linked to COVID-19 infection or vaccination from October 2021 to March 2023.
  • The research analyzed data from 729 cases and 2,916 matching controls, assessing factors like COVID-19 vaccination status, family history, substance use, and physical activity.
  • Results indicated that receiving at least one COVID-19 vaccine dose reduced the likelihood of sudden death, while factors such as past hospitalization for COVID-19, family history of sudden deaths, binge drinking, and intense physical activity increased the risk.
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  • Cytokines, particularly those from the interleukin (IL)-10 family, play crucial roles in managing inflammation and immune responses during COVID-19.
  • Researchers measured the plasma levels of various IL-10 family cytokines in COVID-19 patients across different timeframes post-infection.
  • Findings indicate that cytokine levels decrease over time and severe cases of COVID-19 have higher levels of these cytokines compared to mild cases, suggesting significant immune response variations in recovered patients.
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Background: Premature babies need to develop similarly to fetuses of the same gestational age. The majority of premature neonates experience a growth-restricted status while in the patent ductus arteriosus (PDA). Extrauterine growth failure is a significant barrier for infants with very low birth weight (VLBW).

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Background: The Coronavirus disease 2019 (COVID-19) pandemic increased the utilisation of healthcare services. Such utilization could lead to higher out-of-pocket expenditure (OOPE) and catastrophic health expenditures (CHE). We estimated OOPE and the proportion of households that experienced CHE by conducting a cross-sectional survey of 1200 randomly selected confirmed COVID-19 cases.

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Background: Plasmacytoid and myeloid dendritic cells play a vital role in the protection against viral infections. In COVID-19, there is an impairment of dendritic cell (DC) function and interferon secretion which has been correlated with disease severity.

Results: In this study, we described the frequency of DC subsets and the plasma levels of Type I (IFNα, IFNβ) and Type III Interferons (IFNλ1), IFNλ2) and IFNλ3) in seven groups of COVID-19 individuals, classified based on days since RT-PCR confirmation of SARS-CoV2 infection.

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Background: India did phased measles-rubella supplementary immunisation activities (MR-SIAs; ie, mass-immunisation campaigns) targeting children aged 9 months to less than 15 years. We estimated measles-rubella seroprevalence before and after the MR-SIAs to quantify the effect on population immunity and identify remaining immunity gaps.

Methods: Between March 9, 2018 and March 19, 2020 we did community-based, cross-sectional serosurveys in four districts in India before and after MR-SIAs.

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Article Synopsis
  • The study aimed to explore community perceptions of COVID-19 vaccines in Chennai during the early vaccine rollout phase in India, focusing on various influential factors related to vaccination.
  • Researchers conducted in-depth interviews with healthcare workers, religious leaders, and community representatives, analyzing themes around vaccine availability, trust, concerns, and prioritization.
  • Findings revealed that while some individuals were eager to get vaccinated to restore normalcy and protect loved ones, fears of side effects, misinformation, and doubts about vaccine safety contributed to hesitancy, highlighting the need for effective communication strategies.
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A growing number of organisations, including medical associations, recommend that research subjects should be given the option of being informed about the general outcome and results of the study. We recently completed a study involving nine serosurveys from 2018 to 2020 in five districts of India among three age groups (children 9 months to < 5 years; 5 to < 15 years of age, and women 15 to < 50 years of age before and after the measles and rubella (MR) vaccination campaigns). In Palghar district of Maharashtra all individuals in 30 selected clusters were enumerated, and 13 individuals per age group were randomly sampled.

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India witnessed a very strong second wave of coronavirus disease 2019 (COVID-19) during March and June 2021. Newly emerging variants of concern can escape immunity and cause reinfection. We tested newly diagnosed COVID-19 cases during the second wave in Chennai, India for the presence of Immunoglobulin G (IgG) antibodies to estimate the extent of re-infection.

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Background: Examination of CD4+ T cell responses during the natural course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection offers useful information for the improvement of vaccination strategies against this virus and the protective effect of these T cells. Methods: We characterized the SARS-CoV-2-specific CD4+ T cell activation marker, multifunctional cytokine and cytotoxic marker expression in recovered coronavirus disease 2019 (COVID-19) individuals. Results: CD4+ T-cell responses in late convalescent (>6 months of diagnosis) individuals are characterized by elevated frequencies of activated as well as mono, dual- and multi-functional Th1 and Th17 CD4+ T cells in comparison to early convalescent (<1 month of diagnosis) individuals following stimulation with SARS-CoV-2-specific antigens.

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Article Synopsis
  • T cells play a crucial role in protecting against SARS-CoV-2, but their specific types in recovering patients haven't been well-researched.
  • The study measured T cell counts and types in COVID-19 patients at different recovery stages, finding an increase in memory T cells and a decrease in naïve and regulatory T cells over time.
  • Severe COVID-19 cases showed lower lymphocyte counts and different levels of T cell subtypes and specific cytokines, highlighting significant changes in immune response during and after recovery.
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Background: The coronavirus disease 2019 (COVID-19) pandemic has led to disruption in delivering routine healthcare services including routine immunization (RI) worldwide. Understanding the enablers and barriers for RI services during a pandemic is critically important to develop context-appropriate strategies to ensure uninterrupted routine services.

Methods: A community-based, cross-sectional descriptive study was conducted in five different states of India, nested within an ongoing multicentric study on RI.

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Introduction: India experienced 2 waves of COVID-19 pandemic caused by SARS-CoV-2 and reported the second highest caseload globally. Seroepidemiologic studies were done to track the course of the pandemic. We systematically reviewed and synthesized the seroprevalence of SARS-CoV-2 in the Indian population.

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Novel 3D-biomaterial scaffold is constructed having a combination of a new quaternary ammonium silane (k21) antimicrobial impregnated in 3D collagen printed scaffolds cross linked with Riboflavin in presence of d-alpha-tocopheryl poly(ethyleneglycol)-1000-succinate. Groups of "0.1% and 0.

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