Bio-nanoparticles have created a new era of rapid, harmless and nontoxic drugs for various biomedical applications. The nanoparticles (NPs) of rare earth metal oxides attract researcher's attention due to their excellent chemical and physical properties that exhibit potential activity against disease causing pathogens. () abul is a medicinal plant whose leaves are effectively used for the synthesis of neodymium oxide (NdO) NPs.
View Article and Find Full Text PDFIn this work, extract from leaves of Couroupita guianensis (C.guianensis) abul was used as a potential reducing agent for the synthesis of lanthanum oxide (LaO) nanoparticles (NPs). In addition, the morphology and several physicochemical properties of the LaO NPs were improved by introducing the ionic liquid of 1-butyl 3-methyl imidazolium tetra fluoroborate (BMIM BF) as a stabilizing agent.
View Article and Find Full Text PDFBackground: (SK), a polyherbal decoction containing four medicinal plants has been used in Siddha system of medicine, practiced in Southern parts of India for the management of urolithiasis.
Objective: The present study is carried out to scientifically validate the traditional claim and to study the mechanism of action of the drug.
Materials And Methods: In the present study, anti-urolithiatic effect of SK was evaluated in Sprague-Dawley rats using ethylene glycol through drinking water and intraperitoneal injection of sodium oxalate.
Sirupeellai samoola kudineer (SK), a polyherbal decoction, has been used in Siddha system of medicine for the management of Urolithiasis. Since, there exists no documentation of preclinical toxicological evaluation of SK earlier, in the present study, acute and subacute toxicity of SK was assessed in Sprague Dawley rats as per OECD guideline 423 and 407, respectively. In the acute toxicity study, SK did not produce any toxic signs at a dose level of 50 ml/kg b.
View Article and Find Full Text PDFA toxicological study was carried out in rats with a Siddha preparation, milk extracts of Semecarpus anacardium nuts. The effect of acute (72 h) and subacute (30 days) treatment of the drug with different dosage on liver and kidney functions and hematological parameters were studied. The acute toxicity studies with this drug did not produce mortality at any dose level given (75-2000 mg/kg body weight).
View Article and Find Full Text PDFAflatoxin B1 is an important consideration in the aetiology of human and animal hepatocellular carcinoma. The influence of the drug, Semecarpus anacardium Linn. nut extract, on hepatocarcinogenicity of aflatoxin B1 was evaluated in adult albino male Wistar rats.
View Article and Find Full Text PDFOxygen derived free radicals are known to play an important role in the etiology of tissue injury in rheumatoid arthritis. The effect of milk extract of Semecarpus anacardium nuts at the dose level of 150 mg/kg body weight for 14 days on adjuvant arthritis was studied for gaining insight into the intrigue disease in relation to the lipid peroxidation and antioxidant defence system. Increased lipid peroxides' levels in both plasma and tissues (liver, kidney and heart) of adjuvant arthritis was significantly decreased by the administration of the drug.
View Article and Find Full Text PDFLysosomal acid hydrolases are thought to play an important role in inflammation associated with rheumatoid arthritis. A Siddha preparation of Semecarpus anacardium nut extract called Serankottai Nei was tested for its capacity to stabilize lysosomes obtained from liver and kidney of adjuvant-induced arthritic animals. Lysosomal membrane stability was measured by determining the release of acid hydrolases from the lysosomes.
View Article and Find Full Text PDF1. Adjuvant-induced arthritis in rats is used as a pathologic model for chronic inflammatory disease to evaluate the efficacy of therapeutic agents. 2.
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