Publications by authors named "Muthu Sendhil Kumaran"

We describe a rare case of cutaneous phaeohyphomycosis by Veronaea botryosa in a renal transplant recipient from India. The patient presented with a nodule on the dorsum of right hand which resolved completely after 6 months of voriconazole therapy. The identity of the fungus was confirmed by sequencing internal transcribed spacer (ITS) region of rDNA.

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Article Synopsis
  • Chronic inducible urticaria (CIndU) lasts longer than 6 weeks and is triggered by specific factors, but research on its severity and treatment is limited compared to chronic spontaneous urticaria (CSU).
  • A study reviewed data from 222 CIndU patients and 226 CSU controls, finding that both groups were similar in age and gender, but CIndU patients had significantly lower CRP levels and a poorer quality of life score (CU-QOL).
  • CIndU patients required more frequent antihistamine adjustments (80% vs. 52% in CSU) and took longer to achieve remission, averaging 60 days compared to 27.77 days for CSU patients.
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  • Dermatitis artefacta (DA) is a rare skin disorder primarily seen in late adolescents and young adults, often challenging to diagnose.
  • A 17-year-old girl experienced unexplained linear skin lesions for 11 months, resulting in significant school absences; her examination revealed characteristics typical of DA.
  • Treatment involved N-acetyl cysteine and psychiatric evaluation, emphasizing the need for a comprehensive approach to manage DA due to its links with psychological issues.
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Background Cold urticaria (ColdU) is classified as a subtype of chronic inducible urticaria characterised by recurring pruritic wheals and/or angioedema upon exposure to cold stimuli. However, very limited data is available on ColdU specifically among Indians. Objectives The aim of this study was to describe the clinico-epidemiological characteristics and treatment response in North Indian patients diagnosed with ColdU.

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Background: Comprehensive long-term follow-up data regarding chronic spontaneous urticaria (CSU) among general populations, especially from the Indian subcontinent is scanty.

Aim And Objectives: The aim of the study were to analyze the clinico-epidemiological profile, comorbidities of CSU patients, and factors affecting patient response to various doses of levocetirizine.

Materials And Methods: In this retrospective cohort study, complete history regarding demographic profile, clinical examination, investigations, treatment given, and follow-up details of all CSU patients attending urticaria clinic between 2010 and 2019 were analyzed.

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  • Non-cultured epidermal suspension (NCES) is a popular surgical treatment for stable vitiligo, and the method of delivering the suspension significantly affects the results.
  • A study compared two delivery methods: conventional suspension delivery after manual dermabrasion (CSMD) and tattooing pen-assisted suspension delivery (TPSD) in 36 patients, examining repigmentation success over 24 weeks.
  • Results showed that CSMD achieved better repigmentation in 86.1% of cases compared to 61.1% for TPSD, and while CSMD had more complications, TPSD had no perilesional halo effects, suggesting room for improvement in tattooing pen techniques.
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Background: Role of complement fraction 5a (C5a), interleukin (IL)-9, and apolipoprotein (apo) A-IV as biomarkers of disease severity and antihistamine response in chronic spontaneous urticaria (CSU) remains elusive.

Objective: To identify the role of C5a, IL-9, and apo A-IV as potential biomarkers in predicting disease severity and antihistamine response in CSU patients.

Methods: This was a prospective observational study of 95 patients and 42 controls.

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Background: Narrowband ultraviolet B (NB-UVB) phototherapy promotes stability and repigmentation in vitiligo. No studies have compared targeted NB-UVB with whole-body NB-UVB in treatment of acral vitiligo.

Objectives: This randomized split-body study compared whole-body NB-UVB with targeted NB-UVB in inducing stability and repigmentation in acral vitiligo.

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Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is an idiosyncratic severe cutaneous adverse reaction that may be potentially life-threatening. Recently, a simple scoring system for the early screening of DRESS patients was derived by combining hsCRP levels, the eosinophil count, and the total body surface area (CET score). The objectives of this study were validating the CET score, and calculating its lead time advantage and cost-benefits compared to RegiSCAR scoring.

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Background: Hereditary angio-oedema (HAE) is a rare autosomal dominant disorder characterized clinically by recurrent episodes of nonpruritic subcutaneous and/or submucosal oedema. Laryngeal oedema is the commonest cause of mortality in patients with HAE. Prior to the availability of first-line treatment options for the management of HAE, mortality was as high as 30%.

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Background: Multiple vaccines were introduced during 2020-2021 to combat Covid-19 pandemic, being one of the successful vaccine programmes in the present era. Very few studies are available on status of chronic urticaria (CU) post Covid-19 vaccination.

Aim: The aim of this study was to study effect of Covid-19 vaccination on our urticaria cohort.

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Introduction There is ambiguity regarding usage of tranexamic acid for melasma in India, be it in its pre-administration evaluation, administration route, dosing or monitoring. Hence, we conducted this study to understand various tranexamic-acid prescribing patterns and provide practical guidelines. Materials and methods A Google-form-based questionnaire (25-questions) was prepared based on the key areas identified by experts from the Pigmentary Disorders Society, India and circulated to practicing dermatologists across the country.

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Background: Concern about disease exacerbations and fear of reactions after coronavirus disease 2019 (COVID-19) vaccinations are common in chronic urticaria (CU) patients and may lead to vaccine hesitancy.

Objective: We assessed the frequency and risk factors of CU exacerbation and adverse reactions in CU patients after COVID-19 vaccination.

Methods: COVAC-CU is an international multicenter study of Urticaria Centers of Reference and Excellence (UCAREs) that retrospectively evaluated the effects of COVID-19 vaccination in CU patients aged ≥18 years and vaccinated with ≥1 dose of any COVID-19 vaccine.

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