Microbiome flexibility enhances the resilience of the potentially invasive coral Tubastraea aurea to abrupt environmental changes: Insights from a shallow water hydrothermal vent transplantation study.

To comprehend the effects of potentially invasive coral Tubastraea aurea on marine ecosystems, it is crucial to understand their adaptive strategies to survive environmental changes and perturbations. Therefore, a cross-transplantation study was conducted to assess the microbiome's role in the resilience of T. aurea to sudden environmental changes.

Surface Area-Enhanced Cerium and Sulfur-Modified Hierarchical Bismuth Oxide Nanosheets for Electrochemical Carbon Dioxide Reduction to Formate.

Electrochemical carbon dioxide reduction reaction (ECORR) is a promising approach to synthesize fuels and value-added chemical feedstocks while reducing atmospheric CO levels. Here, high surface area cerium and sulfur-doped hierarchical bismuth oxide nanosheets (Ce@S-BiO) are develpoed by a solvothermal method. The resulting Ce@S-BiO electrocatalyst shows a maximum formate Faradaic efficiency (FE) of 92.

The Effectiveness of High-Fidelity Simulation on Clinical Competence Among Nursing Students.

Introduction: Clinical competence is a pre-requisite for every student nurse to showcase their proficiency in providing quality nursing care. Effective clinical experience during the study period plays a pivotal role in developing clinical competence among nursing students. Hence, the purpose of the study was to find the effectiveness of high fidelity simulation (HFS) on clinical competence among nursing students.

Untwisting healthcare access disparities: A comprehensive analysis of demographic, socio-economic and racial disparities impacting patient outcomes in myocardial infarction patients.

Introduction: Myocardial infarction (MI) is one of the most life-threatening pathologies characterized by sudden cardiac death and is among the leading causes of mortality in the developed world.

Aims: This study investigates the demographic, socio-economic, and healthcare access disparities in the US among patients with myocardial infarction (MI).

Methodology: This was a retrospective original research study conducted using the BRFSS (Behavioural risk factor surveillance system) database of CDC (Centers for disease control and prevention).

Untwisting healthcare access disparities: A comprehensive analysis of demographic, socio-economic and racial disparities impacting patient outcomes in myocardial infarction patients.

Introduction: Myocardial infarction (MI) is one of the most life-threatening pathologies characterized by sudden cardiac death and is among the leading causes of mortality in the developed world.

Aims: This study investigates the demographic, socio-economic, and healthcare access disparities in the US among patients with myocardial infarction (MI).

Methodology: This was a retrospective original research study conducted using the BRFSS (Behavioural risk factor surveillance system) database of CDC (Centers for disease control and prevention).

Review of Transition Metal Chalcogenides and Halides as Electrode Materials for Thermal Batteries and Secondary Energy Storage Systems.

Transition metal chalcogenides and halides (TMCs and TMHs) have been extensively used and reported as electrode materials in diverse primary and secondary batteries. This review summarizes the suitability of TMCs and TMHs as electrode materials focusing on thermal batteries (utilized for defense applications) and energy storage systems like mono- and multivalent rechargeable batteries. The report also identifies the specific physicochemical properties that need to be achieved for the same materials to be employed as cathode materials in thermal batteries and anode materials in monovalent rechargeable systems.

Nurses Experience and Perceived Challenges of Using Nonpharmacological Pain Interventions for Musculoskeletal Pain: A Qualitative Study.

Introduction: Current musculoskeletal pain management guidelines encourage utilizing nonpharmacological pain measures. Despite their positive effect in alleviating musculoskeletal pain, nurses reported negative attitudes toward utilizing nonpharmacological pain measures. Therefore, assessing nurses' perception of nonpharmacological pain measures is essential to promote patient comfort.

Geometric and Electronic Structural Engineering of Isolated Ni Single Atoms for a Highly Efficient CO Electroreduction.

Tuning the coordination environment and geometric structures of single atom catalysts is an effective approach for regulating the reaction mechanism and maximize the catalytic efficiency of single-atom centers. Here, a template-based synthesis strategy is proposed for the synthesis of high-density NiN sites anchored on the surface of hierarchically porous nitrogen-doped carbon nanofibers (Ni-HPNCFs) with different coordination environments. First-principles calculations and advanced characterization techniques demonstrate that the single Ni atom is strongly coordinated with both pyrrolic and pyridinic N dopants, and that the predominant sites are stabilized by NiN sites.

Self-care Management in Heart Failure Using Roy Adaptation Theory-guided Intervention in the United Arab Emirates.

Purpose: To assess the knowledge and practice of self-care management among patients with heart failure (HF) after Roy adaptation theory-guided educational program.

Methodology: One group quasi-experimental pretest-posttest design of 30 purposively selected patients with HF was conducted. Outcomes were examined under three domains: knowledge, self-care maintenance, and monitoring pre- and post-intervention, using a validated instrument based on four adaptive modes of Roy's theory.

Discernment on assistive technology for the care and support requirements of older adults and differently-abled individuals.

Assistive technology for the differently abled and older adults has made remarkable achievements in providing rehabilitative, adaptive, and assistive devices. It provides huge assistance for people with physical impairments to lead a better self-reliant daily life, in terms of mobility, education, rehabilitation, etc. This technology ranges from simple hand-held devices to complex robotic accessories which promote the individual's independence.

Metallic Metastable Hybrid 1T'/1T Phase Triggered Co,PSnS Nanosheets for High Efficiency Trifunctional Electrocatalyst.

The development of trifunctional electrocatalyst for oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER) with deeply understanding the mechanism to enhance the electrochemical performance is still a challenging task. In this work, the distorted metastable hybrid-phase induced 1T'/1T Co,PSnS nanosheets on carbon cloth (1T'/1T Co,PSnS @CC) is prepared and examined. The density functional theoretical (DFT) calculation suggests that the distorted 1T'/1T Co,PSnS can provide excellent conductivity and strong hydrogen adsorption ability.

Tuberous xanthoma with cardiac failure in a child.

A 14-year-old girl presented with gradually progressive breathlessness for 3 weeks. On evaluation, it was found that she had left ventricular hypertrophy and nonprogressive R wave in ECG. An echocardiogram revealed aortic stenosis and severe left ventricular dysfunction.

Emerging Feature Extraction Techniques for Machine Learning-Based Classification of Carotid Artery Ultrasound Images.

Plaque deposits in the carotid artery are the major cause of stroke and atherosclerosis. Ultrasound imaging is used as an early indicator of disease progression. Classification of the images to identify plaque presence and intima-media thickness (IMT) by machine learning algorithms requires features extracted from the images.

Performance Analysis of Machine Learning and Deep Learning Architectures on Early Stroke Detection Using Carotid Artery Ultrasound Images.

Atherosclerotic plaque deposit in the carotid artery is used as an early estimate to identify the presence of cardiovascular diseases. Ultrasound images of the carotid artery are used to provide the extent of stenosis by examining the intima-media thickness and plaque diameter. A total of 361 images were classified using machine learning and deep learning approaches to recognize whether the person is symptomatic or asymptomatic.

Smart access development for classifying lung disease with chest x-ray images using deep learning.

Recently the world has come across a pandemic disease known as covid-19. The presence of symptoms of covid-19 and pneumonia may be alike to other types of lung illnesses. So, because of this, it is difficult for the affected person or medical experts to identify the condition.

Unanticipated diagnosis of skeletal muscle Kaposi sarcoma: a case report.

Kaposi sarcoma (KS) is a cancer, characteristically manifesting as red or purple patches of abnormal tissue growing subcutaneously around the mouth, nose, and throat. Primary musculoskeletal KS is a never reported as skeletal muscles sarcomas are first differentials. Pertaining to the musculoskeletal system complicity of KS, African and classic KS lesions are inclined to manifest lesion in the peripheral skeleton.

Amla (Emblica officinalis) improves hepatic and renal oxidative stress and the inflammatory response in hypothyroid female wistar rats fed with a high-fat diet.

Background: We investigated the protective effects of amla (Emblica officinalis) on the pathogenesis of oxidative stress (OS) and inflammatory response in hypothyroid rats fed with a high-fat diet (HFD) as an experimental model of hypothyroidism (HT) with obesity.

Methods: A total of 80 female wistar rats (5-months-old) were divided into eight different groups. Propylthiouracil (PTU) and HFD were used to induce the experimental HT and obesity, respectively.

2D:4D Ratio and its Implications in Medicine.

Digit ratios, especially 2D:4D ratio, a potential proxy marker for prenatal androgen exposure shows sexual dimorphism. Existing literature and recent research show accumulating evidence on 2D:4D ratio showing correlations with various phenotypic traits in humans. Ratio of 2D:4D is found to correlate negatively to testosterone and positively to oestrogen in the foetus.

Quantitative Detection of Nucleoside Analogues by Multi-enzyme Biosensors using Time-Resolved Kinetic Measurements.

Fast, simple and cost-effective methods for detecting and quantifying pharmaceutical agents in patients are highly sought after to replace equipment and labor-intensive analytical procedures. The development of new diagnostic technology including portable detection devices also enables point-of-care by non-specialists in resource-limited environments. We have focused on the detection and dose monitoring of nucleoside analogues used in viral and cancer therapies.

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.

Myosin light chain kinase (MLCK)-dependent phosphorylation of the regulatory light chain (RLC) of cardiac myosin is known to play a beneficial role in heart disease, but the idea of a phosphorylation-mediated reversal of a hypertrophic cardiomyopathy (HCM) phenotype is novel. Our previous studies on transgenic (Tg) HCM-RLC mice revealed that the D166V (Aspartate166 → Valine) mutation-induced changes in heart morphology and function coincided with largely reduced RLC phosphorylation in situ. We hypothesized that the introduction of a constitutively phosphorylated Serine15 (S15D) into the hearts of D166V mice would prevent the development of a deleterious HCM phenotype.

Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics.

Familial hypertrophic cardiomyopathy (HCM) is associated with mutations in sarcomeric proteins, including the myosin regulatory light chain (RLC). Here we studied the impact of three HCM mutations located in the NH2 terminus of the RLC on the molecular mechanism of β-myosin heavy chain (MHC) cross-bridge mechanics using the in vitro motility assay. To generate mutant β-myosin, native RLC was depleted from porcine cardiac MHC and reconstituted with mutant (A13T, F18L, and E22K) or wild-type (WT) human cardiac RLC.

Redesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomography.

Recent advances in nuclear medicine have allowed for positron emission tomography (PET) to track transgenes in cell-based therapies using PET reporter gene/probe pairs. A promising example for such reporter gene/probe pairs are engineered nucleoside kinases that effectively phosphorylate isotopically labeled nucleoside analogues. Upon expression in target cells, the kinase facilitates the intracellular accumulation of radionuclide monophosphate, which can be detected by PET imaging.