Dynamics of Treatment Response to Faricimab for Diabetic Macular Edema.

This study analyzes the dynamics of short-term treatment response to the first intravitreal faricimab injection in eyes with diabetic macular edema (DME). This retrospective, single-center, clinical trial was conducted at the Department of Ophthalmology, University Hospital Zurich. Patients with treatment-naïve and pretreated DME were included.

Sterile Intraocular Inflammation Associated With Faricimab.

Importance: Randomized clinical trials are conducted to establish both drug safety and efficacy. However, evidence of adverse events associated with these drugs in the clinical practice setting can be of value at generating hypotheses regarding less common safety issues, even if causality cannot be determined.

Objective: To present and analyze cases of intraocular inflammation associated with faricimab therapy in patients referred to a single European institution.

Transport, trapping, triplet fusion: thermally retarded exciton migration in tetracene single crystals.

Efficient exciton migration is crucial for optoelectronic organic devices. While the transport of triplet excitons is generally slow compared to singlet excitons, triplet exciton migration in certain molecular semiconductors with endothermic singlet fission appears to be enhanced by a time-delayed regeneration of the more mobile singlet species triplet fusion. This combined transport mechanism could be exploited for devices, but the interplay between singlet fission and triplet fusion, as well as the role of trap states is not yet well understood.

Real-World Weekly Efficacy Analysis of Faricimab in Patients with Age-Related Macular Degeneration.

: This study entailed a weekly analysis of real-world data (RWD) on the safety and efficacy of intravitreal (IVT) faricimab in neovascular age-related macular degeneration (nAMD). : A retrospective, single-centre clinical trial was conducted at the Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland, approved by the Cantonal Ethics Committee of Zurich, Switzerland. Patients with nAMD were included.

Imaging Assessment of Peripapillary Vessel Diameters in Postmortem Eyes.

Purpose: Proof of concept of retinal vessel diameter measurements in human postmortem eyes.

Methods: En face near-infrared (IR) images and optical coherence tomography (OCT) of the optic nerve head (ONH) were captured with a Heidelberg Engineering Spectralis (Spectralis, version 7.0.

Efficacy of Subthreshold Micropulse Laser for Central Serous Chorioretinopathy.

Purpose: To evaluate the efficacy of a subthreshold micropulse laser (SML) in patients with central serous chorioretinopathy (CSCR).

Methods: Retrospective clinical study conducted at the Departments of Ophthalmology at a university and a municipal hospital in Zurich, Switzerland. We enrolled acute and chronic CSCR patients with persistent subretinal fluid (SRF) treated with SML.

Ophthalmological Outcomes in Patients with Susac Syndrome.

Background: To report ophthalmological outcomes and treatment regimen in patients with Susac syndrome.

Methods: This is a retrospective analysis of patients with Susac syndrome treated between November 2015 and March 2023. Multimodal imaging findings, ophthalmic examination data, information on neurological and sensorineural involvement, and therapeutic regimen were reviewed.

Evaluation of Increase in Retinal Thickness as Diagnostic Marker in Central Artery Occlusion.

Purpose: To evaluate the increase in retinal thickness as a marker in predicting the onset of central retinal artery occlusions.

Methods: Retrospective clinical study conducted at one Swiss hospital. Electronic records were filtered for patients with artery occlusions.

A Novel Technique of Aseptic Manufacture of Autologous Serum Eye Drops (ASEDs) and Sterility Analysis of the Bottled Ophtioles.

Purpose: To introduce a novel technique of the aseptic manufacture of autologous serum eye drops (ASEDs) with a prefiltered closed system and to analyze the sterility of the produced ophtioles between 2018 and 2022.

Methods: This is a prospective single-center study conducted at the Department of Ophthalmology at a Swiss University Hospital between 2018 and 2022. For regulatory reasons, closed systems for manufacturing ASEDs are strongly recommended.

Vitamin A deficiency retinopathy related to medical interventions in a Swiss cohort: a case series.

Aims Of The Study: Vitamin A deficiency retinopathy is a potentially blinding disease. In developed countries, vitamin A deficiency due to malnutrition is rare. However, vitamin A deficiency can be caused by malabsorption resulting from bowel resection or medication.

A New Family of Layered Metal-Organic Semiconductors: Cu/V-Organophosphonates.

Herein, we report the design and synthesis of a layered redox-active, antiferromagnetic metal organic semiconductor crystals with the chemical formula [Cu(H O) V(µ-O)(PPA) ] (where PPA is phenylphosphonate). The crystal structure of [Cu(H O) V(µ-O)(PPA) ] shows that the metal phosphonate layers are separated by phenyl groups of the phenyl phosphonate linker. Tauc plotting of diffuse reflectance spectra indicates that [Cu(H O) V(µ-O)(PPA) ] has an indirect band gap of 2.

Analysis of Blood Flow in the Macula and Optic Nerve Head in Healthy Young Volunteers Using Laser Speckle Flowgraphy.

Purpose: To assess optic nerve head (ONH) and macular blood flow in young healthy volunteers using laser speckle flowgraphy (LSFG).

Methods: This is a prospective single-center study conducted at the Department of Ophthalmology, University Hospital Zurich from May to November 2021. Young, healthy men aged ≥ 18 years without ocular or systemic diseases were included.

Natural Course of Solar and Laser-Associated Retinal and Macular Injuries at a Primary Care Hospital in Switzerland.

Background: Solar and laser-associated retinopathies are rare occurrences. The two retinopathies are both photo-induced but differ in the involved intensity and duration of exposure. The purpose of this study was to evaluate the clinical features and natural course of these two entities, with a focus on the changes in the outer retina over time.

Severe Complications after Corneal Collagen Cross-Linking (CXL).

Purpose: To present a case series of rare and severe complications after corneal collagen cross-linking (CXL) of keratoconus patients.

Methods: Single-center descriptive case series covering the period of 2012 to 2022 at the Department of Ophthalmology at the University Hospital, Zurich, Switzerland.

Results: We present four eyes of four patients that showed severe unusual complications within the first month after CXL.

Age-dependent retinal neuroaxonal degeneration in children and adolescents with Leber hereditary optic neuropathy under idebenone therapy.

Background: The aim of this study was to investigate the neuroretinal structure of young patients with Leber hereditary optic neuropathy (LHON).

Methods: For this retrospective cross-sectional analysis, the peripapillary retinal nerve fiber layer (pRNFL) thickness and the macular retinal layer volumes were measured by optical coherence tomography. Patients aged 12 years or younger at disease onset were assigned to the childhood-onset (ChO) group and those aged 13-16 years to the early teenage-onset (eTO) group.

Analysis of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) Parameters in Young Adults after SARS-CoV-2 Infection (COVID-19) Compared with Healthy Young Controls.

Purpose: To compare retinal changes in young adults with previous SARS-CoV-2 infection with healthy young controls using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).

Methods: This prospective single-center study was conducted at the University Hospital of Zurich, Zurich, Switzerland. Participants were imaged from May to November 2021 using the device (Visionix International SAS, Pont-de-l'Arche, France).

Smartphone Slit Lamp Imaging-Usability and Quality Assessment.

Purpose: To assess the usability and image quality of a smartphone adapter for direct slit lamp imaging.

Methods: A single-center, prospective, clinical study conducted in the Department of Ophthalmology at the University Hospital Zurich, Switzerland. The smartphone group consisted of 26 medical staff (consultants, residents, and students).

Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification.

To investigate associations and predictive factors between macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naïve neovascular age-related macular degeneration (AMD). Methods: Multimodal imaging was retrospectively reviewed for druse type (soft drusen, subretinal drusenoid deposits (SDDs) or mixed) and MNV type (MNV 1, MNV 2, MNV 1/2 or MNV 3). The Consensus on Neovascular AMD Nomenclature (CONAN) classification was used for characterizing MNV at baseline.

Novel surgical technique of sutureless artificial iris and intraocular lens scleral fixation using Yamane technique.

Purpose: To describe a novel surgical technique of a combined implantation of an artificial iris and a scleral fixated intraocular lens (IOL) using flanged IOL haptics ("Yamane" technique).

Observations: The suturelessly implanted artificial iris-IOL-sandwich was stable with good functional as well as aesthetic results. However, our case showed a postoperative intraocular pressure rise.