Publications by authors named "Muteeba Azhar"
The rise of resistance to antiretroviral drugs due to mutations in human immunodeficiency virus-1 (HIV-1) protease is a major obstacle to effective treatment. These mutations alter the drug-binding pocket of the protease and reduce the drug efficacy by disrupting interactions with inhibitors. Traditional methods, such as biochemical assays and structural biology, are crucial for studying enzyme function but are time-consuming and labor-intensive.
View Article and Find Full Text PDFPyocins and Beyond: Exploring the World of Bacteriocins in Pseudomonas aeruginosa.
Probiotics Antimicrob Proteins
July 2024
Article Synopsis
- Pseudomonas aeruginosa is an opportunistic pathogen that causes serious health-related infections in various species and is increasingly resistant to common antibiotics.
- The rise of multi-drug resistant strains is prompting a search for alternative antimicrobial treatments, leading researchers to explore pyocins—antimicrobial peptides produced by bacteria.
- Pyocins exhibit strong antibacterial properties, particularly against other drug-resistant P. aeruginosa strains, making them promising candidates for new therapies due to their ability to disrupt antibiotic-resistant biofilms.