Publications by authors named "Mustapha Jaber"
Article Synopsis
- The androgen receptor (AR) is important for prostate cell differentiation, but its role changes in cancer, leading to enhanced tumor traits due to altered chromatin interactions.
- This study reveals that the NSD2 enzyme, which is overexpressed in prostate cancer, is crucial for the function of tumor-specific AR enhancers by affecting their chromatin makeup.
- Targeting both NSD1 and NSD2 may provide an effective treatment strategy for advanced prostate cancer, especially seen with a specialized degrader that shows strong effects in AR-driven cancer models.
Article Synopsis
- The study investigates how social vulnerability within a community impacts outcomes for patients involved in motor vehicle collisions (MVCs), focusing on the relationship between a patient’s home environment and the crash location.
- Researchers used crash data from Michigan and a social vulnerability index (SVI) to categorize areas by vulnerability levels, analyzing the interaction between home and crash environments.
- Results indicated that most MVCs occurred in areas with moderate social vulnerability, and while higher home SVI was associated with increased mortality odds initially, this significance diminished when vehicular and environmental factors were included in the analysis.
The androgen receptor (AR) is a ligand-responsive transcription factor that binds at enhancers to drive terminal differentiation of the prostatic luminal epithelia. By contrast, in tumors originating from these cells, AR chromatin occupancy is extensively reprogrammed to drive hyper-proliferative, metastatic, or therapy-resistant phenotypes, the molecular mechanisms of which remain poorly understood. Here, we show that the tumor-specific enhancer circuitry of AR is critically reliant on the activity of Nuclear Receptor Binding SET Domain Protein 2 (NSD2), a histone 3 lysine 36 di-methyltransferase.
View Article and Find Full Text PDFThe switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling and is altered in over 20% of cancers. Here we developed a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4, called AU-15330. Androgen receptor (AR) forkhead box A1 (FOXA1) prostate cancer cells are exquisitely sensitive to dual SMARCA2 and SMARCA4 degradation relative to normal and other cancer cell lines.
View Article and Find Full Text PDFArticle Synopsis
- Metastatic neuroendocrine prostate cancer (NEPC) is an aggressive form of cancer with increasing incidence, and the role of long noncoding RNAs (lncRNAs) in its development is not well understood.
- Researchers identified conserved lncRNAs involved in NEPC by analyzing patient-derived models, finding LINC00261 significantly upregulated in NEPC cases.
- LINC00261 enhances cancer growth and spread by affecting other genes (CBX2 and FOXA2) through two different mechanisms, making it a potential target for new treatments and a marker for diagnosis.