Development of a novel laboratory photodynamic therapy device: automated multi-mode LED system for optimum well-plate irradiation.

Photodynamic therapy (PDT) is a targeted treatment method that utilizes a photosensitizer (PS) to induce cytotoxicity in malignant and non-malignant tumors. Optimization of PDT requires investigation of the selectivity of PS for the target tissues, irradiating light source, irradiation wavelengths, fluence rate, fluence, illumination mode, and overall treatment plan. In this study, we developed the Multi-mode Automatized Well-plate PDT LED Laboratory Irradiation System (MAWPLIS), an innovative device that automates time-consuming well plate light dosage/PS dose measurement experiment.

Assessing cytotoxic activities, theoretical and molecular docking calculations of phthalocyanines bearing cinnamyloxy-groups.

Cancer has been recognized as one of the deadliest diseases in the world in recent years. By chemically tailoring specific properties, anticancer agents can be prepared very effectively for the treatment of various cancer types. In this manner, as anticancer agents, a series of soluble metal-free and metallophthalocyanines carrying cinnamyloxy-groups at peripheral β-positions have been prepared.

Complex bio rhythms.

Complex biorhythms are characteristic of ubiquitous phenomena appearing in many disciplines of human knowledge. This Special Issue collects articles devoted to different complex biorhythms phenomena such as cardiac dynamics, Covid-19 dynamics, dynamics of neural networks, cell dynamics, and a few articles devoted to general methods. It furnishes a rich overview of the field and can stimulate and inspire further researches.

Investigation of the therapeutic effect of 5-aminolevulinic acid based photodynamic therapy on hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a heterogeneous type of cancer and current treatment options limit successful therapy outcomes. Photodynamic therapy (PDT) has attracted attention as an alternative approach in the treatment of different types of cancer. However, there is no study in the literature regarding the effect of PDT on HCC, in vitro.

The effect of attentional focusing strategies on EMG-based classification.

Earlier studies showed that external focusing enhances motor performance and reduces muscular activity compare to internal one. However, low activity is not always desired especially in case of Human-Machine Interface applications. This study is based on investigating the effects of attentional focusing preferences on EMG based control systems.

Development of new descriptor for melanoma detection on dermoscopic images.

Early detection of melanoma has critical importance for the success of the treatment. However, a successful early diagnosis is only possible with the existence of discriminative features. In this study, a new descriptor based on the number of colors was developed in order to successfully diagnose lesions of melanoma.

Investigation of LED-based photodynamic therapy efficiency on breast cancer cells.

Photodynamic therapy (PDT) is based on special light source, photosensitizer (PS), and in the presence of oxygen. Different light sources have been used for PDT applications. Recent studies have focused on LED light sources for PDT applications due to reducing the cost of laser-based PDT and providing easy access for research laboratory or clinic facilities.

Optimization of 5-aminolevulinic acid-based photodynamic therapy protocol for breast cancer cells.

Background: Photodynamic therapy (PDT) is a therapeutic strategy for the treatment of cancer. 5-aminolevulinic acid (5-ALA) as a precursor of the protoporphyrin IX (PpIX) has a great potential for PDT application. Although 5-ALA-based PDT has been studied in many pre-clinical and clinical studies for breast cancer, there are different PDT application protocols in the literature.

A New handheld singlet oxygen detection system (SODS) and NIR light source based phantom environment for photodynamic therapy applications.

Photodynamic therapy (PDT) is an emerging treatment modality in various areas such as cancer treatment and disinfection. The photosensitizer and oxygen have crucial roles for effective PDT treatment. The quantitative evaluation of singlet oxygen, which is a gold standard for monitoring effective treatment, remains as an important problem for PDT.

An optoelectromechanical tactile sensor for detection of breast lumps.

We developed a compact tactile imaging (TI) system to guide the clinician or the self-user for noninvasive detection of breast tumors. Our system measures the force distribution based on the difference in stiffness between a palpated object and an abnormality within. The average force resolution, force range, and the spatial resolution of the device are 0.

Relationship between vibrotactile detection threshold in the Pacinian channel and complex mechanical modulus of the human glabrous skin.

The goal of this study was to investigate the relationship between the psychophysical vibrotactile thresholds of the Pacinian (P) channel and the mechanical properties of the skin at the fingertip. Seven healthy adult subjects (age: 23-30) participated in the study. The mechanical stimuli were 250-Hz sinusoidal bursts and applied with cylindrical contactor probes of radii 1, 2, and 3.