Myositis associated with pembrolizumab presenting with myastheniform symptoms: two case reports.

Immune checkpoint inhibitors (ICIs), such as pembrolizumab, have revolutionized cancer treatment by enhancing the immune system's response to malignancies. However, these therapies are associated with immune-related adverse events (irAEs), including neuromuscular complications such as myasthenia gravis, myositis, and myocarditis. We describe two male patients, aged 67 and 68, with small cell and non-small cell lung cancers, who developed progressive neuromuscular symptoms, including ptosis, diplopia, and generalized weakness, after receiving pembrolizumab.

Assessment of the relationship between fractal analysis of mandibular bone and orthodontic treatment duration : A retrospective study.

Purpose: This retrospective study aimed to determine whether a correlation exists between the fractal dimension value and overall orthodontic treatment duration in children and young adults.

Methods: The study included a total of 643 patients (age: 10-25 years) who received orthodontic treatment between January 2015 and March 2020. Patient records and pretreatment panoramic radiographs were evaluated.

Epidemiological and clinical characteristics and management of oropharyngeal tularemia outbreak.

Background/aim: The purpose of this study was to determine the epidemiological and clinical characteristics of patients diagnosed with tularemia and the effectiveness of the administered treatments.

Materials And Methods: Patients treated in our hospital between January 2009 and March 2011 and diagnosed with tularemia were evaluated retrospectively. Patients' epidemiological and clinical characteristics, administered treatments, and posttreatment findings were recorded on patient monitoring forms.

Association of VNTR polymorphisms in DRD4, 5-HTT and DAT1 genes with obesity.

Objective: To investigate the association between VNTR polymorphisms of DRD4, DAT1 and 5-HTT genes and obesity.

Material And Methods: Peripheral blood samples of 234 obese (BMI ≥ 30) and 148 healthy individuals (BMI ≤ 25) were objected to PCR to detect the VNTR of the 2nd intron of 5-HTT, 3rd exon of DRD4 and 3'UTR of DAT1 genes.

Results: The association between obesity and genotype distributions of 5-HTT, DAT1 and DRD4 genes and between obesity and distributions of allele frequencies were tested by Chi Square (χ(2)) test and were not found statistically significant.

The comparison of the anatomical and symptomatic outcomes of sacrocolpopexy and posterior intravaginal slingoplasty.

Introduction And Hypothesis: The aim of this study was to compare abdominal sacrocolpopexy (ASCP) with posterior intravaginal slingoplasty (PIVS) in terms of lower urinary tract symptoms and anatomical restoration.

Methods: Ninety-two patients underwent PIVS and 98 patients underwent ASCP.

Results: Regarding ASCP, the blood loss, operation time, and hospitalization length were 537 ml, 94.

Effects of lipopolysaccharide on blood-brain barrier permeability during pentylenetetrazole-induced epileptic seizures in rats.

We investigated the effects of lipopolysachharide (LPS) on functional and structural properties of the blood-brain barrier (BBB) during pentylenetetrazole (PTZ)-induced epileptic seizures in rats. Arterial blood pressure was significantly elevated during epileptic seizures irrespective of LPS pretreatment. Plasma levels of interleukin (IL)-1, interleukin (IL)-6, nitric oxide (NO) and malondialdehyde (MDA) increased while catalase concentrations decreased in animals treated with LPS, PTZ and LPS plus PTZ.