Publications by authors named "Mustafa N G Al-Kawaaz"
Article Synopsis
- Glioblastoma (GBM) has a poor prognosis, but a combination of the AURKA inhibitor alisertib and the taxane TPI 287 shows promising cytotoxic effects against GBM cells in vitro and improved survival in an animal model.
- In vivo experiments demonstrated that the combination therapy of alisertib and TPI 287 significantly reduced tumor volume and increased survival compared to vehicle treatment, although the difference in survival compared to alisertib alone was only marginal.
- The study found that the combination treatment enhances apoptosis by affecting Bcl-2 family proteins, indicating its potential as a therapy for GBM and supporting further research in this area.