Lifespan Extension by Retrotransposons under Conditions of Mild Stress Requires Genes Involved in tRNA Modifications and Nucleotide Metabolism.

Retrotransposons are mobile DNA elements that are more active with increasing age and exacerbate aging phenotypes in multiple species. We previously reported an unexpected extension of chronological lifespan in the yeast, , due to the presence of Ty1 retrotransposons when cells were aged under conditions of mild stress. In this study, we tested a subset of genes identified by RNA-seq to be differentially expressed in strains with a high-copy number of Ty1 retrotransposons compared with a strain with no retrotransposons and additional candidate genes for their contribution to lifespan extension when cells were exposed to a moderate dose of hydroxyurea (HU).

An algorithmic approach to scalp reconstructive surgery: maximization of cosmetic and functional outcomes.

Background: Scalp reconstruction requires knowledge of scalp anatomy and reconstructive options. Advances in the field have led to numerous procedures being at the disposal of the reconstructive surgeon, expanding treatment options for patients.

Objective: To provide an algorithmic approach and general guidelines to consider when deciding on which scalp surgery will optimize cosmetic and functional outcomes.

Optimized DC-DC converter based on new interleaved switched inductor capacitor for verifying high voltage gain in renewable energy applications.

This paper introduces an optimized DC-DC converter that employs a modified switched inductor-capacitor technique to achieve ultra-high voltage gain for renewable energy systems. The development is based on adding one cell of modified switched inductor (MSL1) with series diodes interleaved with the main switch in the proposed DC-DC converter. The (MSL1) with capacitor operates in resonant mode to reduce current stress across the main switch when the charge in capacitor becomes zero.

Effect of commercially pure titanium implant coated with calcium carbonate and nanohydroxyapatite mixture on osseointegration.

In this research, rabbit femurs were implanted with CP Ti screws coated with a combination of CaCO and nanohydroxyapatite, and the effect on osseointegration was assessed using histological and histomorphometric examination at 2 and 6 weeks. CaCO and nanohydroxyapatite were combined with the EPD to coat the surfaces of the CP Ti screws. The femurs of five male rabbits were implanted with coated and uncoated implant screws.

Farming lifestyle and human milk: Modulation of the infant microbiome and protection against allergy.

There has been an increased prevalence of several allergic manifestations such as food allergy, atopic eczema, allergic rhinitis and asthma. Several explanations have been proposed why this has occurred, but one of the main contributing factors may be the gradual loss of microbial exposures over time in regions where allergy is prevalent. Such exposures occur in individuals who practise a traditional farming lifestyle and are protected against allergy.

Surgical Technique for Anterior Approach for Total Hip Arthroplasty After Bilateral Below-Knee Amputation: A Case Report.

Case: We report a case of a 77-year-old man, with bilateral below-knee amputee, in whom the anterior approach (AA) for a left total hip arthroplasty was used successfully, with 3-year follow-up. This report also summarizes the key studies in the literature on this subject.

Conclusions: The utility of AA surgery performed in the setting of bilateral below-knee amputation has not been previously described.

Hybrid Coils-Based Wireless Power Transfer for Intelligent Sensors.

Most wearable intelligent biomedical sensors are battery-powered. The batteries are large and relatively heavy, adding to the volume of wearable sensors, especially when implanted. In addition, the batteries have limited capacity, requiring periodic charging, as well as a limited life, requiring potentially invasive replacement.

Operative Times in Primary Total Knee Arthroplasty: Can We Predict the Future Based on Contemporary Nationwide Data.

Recently, the Centers for Medicare & Medicaid Services announced its decision to review "potentially misvalued" Current Procedural Terminology (CPT) codes, including those for primary total knee arthroplasty (TKA). CPT 27447 is being reevaluated to determine contemporary relative value units for work value, with operative time considered a primary factor in this revaluation. Despite broader indications for TKA, including extension of the procedure to more complex patient populations, it is unknown whether operative times may remain stable in the future.

Atopic Dermatitis Is Associated With Cervical High Risk Human Papillomavirus Infection.

Objective: High-risk human papillomavirus (hrHPV) infection is more likely to persist and cause cervical cancer in immunosuppressed women. Atopic dermatitis, which is known to affect cell-mediated immunity and skin barrier function, is associated with recalcitrant warts; therefore, we hypothesized that women with atopic dermatitis may be more likely to be positive for hrHPV infection and progress to high-grade cervical dysplasia.

Materials And Methods: A retrospective case-control study of 1,160 women who were either positive or negative for hrHPV in their index cervical cytology.