Fabrication, characterization, and in vivo biocompatibility evaluation of titanium-niobium implants.

In this study, biocompatible titanium-niobium (Ti-Nb) alloys were fabricated by using powder metallurgy methods. Physical, morphological, thermal, and mechanical analyses were performed and their in vivo compatibility was evaluated. Besides α, β, and α″ martensitic phases, α+β Widmanstätten phase due to increasing sintering temperature was seen in the microstructure of the alloys.

Systemic melatonin application increases bone formation in mandibular distraction osteogenesis.

This study aimed to investigate the effects of different doses of systemic melatonin application on new bone formation during mandibular distraction osteogenesis (DO) in rats. Mandibular DO was performed on 30 adult female Sprague-Dawley rats, which were randomly divided into three groups: control group (CNT), melatonin dose 1 (MLT-D1), and melatonin dose 2 (MLT-D2). A five-day latent waiting period and a ten-day distraction phase followed the surgery.

Comparison of the Effects of Local and Systemic Zoledronic Acid Application on Mandibular Distraction Osteogenesis.

Bisphosphonates are antibone resorptive drugs that are used to prevent bone tissue resorption in several skeletal diseases. The aim of this study was to examine the effects of systemic and local applications of zoledronic acid (ZA) on newly regenerated bone in a model of experimental distraction osteogenesis (DO). To do this mandibular DO was applied to 30 adult female Sprague Dawley rats, which were randomly divided into 3 groups: control, DO only, systemic zoledronic acid (SZA), and local zoledronic acid (LZA).

Dynamic renal scintigraphic estimation of deceased donor kidneys in a rat model.

At present a large number of the renal transplantations are being performed from the deceased donors. The success of these transplantations depends on the viability of the deceased donor kidneys. The aim of this study was to investigate the reliability of scintigraphic estimation of function of deceased donor kidneys by comparing the histopathologic and scintigraphic findings.

The effect of simulating body fluid on the structural properties of hydroxyapatite synthesized in the presence of citric acid.

In present work, the effect of citric acid (CA) addition in different amounts (0, 1, 5 and 10 ml) on the structure of hydroxyapatite (HAp) was investigated using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy techniques. The crystallite dimensions, lattice parameters, unit cell volume, crystallinity percentage and Ca/P molar ratio were found to be affected by the CA content. To investigate the influence of CA on the bioactive properties of the HAp samples and to determine the optimum amount of CA, in vitro soaking tests in simulated body fluid (SBF) were performed.

The Effect of Sodium Hyaluronate plus Sodium Chondroitin Sulfate Solution on Peritendinous Adhesion and Tendon Healing: An Experimental Study.

Background: Adhesion formation following tendon injury is a serious clinical problem.

Aims: In this experimental study, the effects of the combination of sodium hyaluronate (HA) and chondroitin sulfate (CS) on peritendinous adhesion and tendon healing were evaluated.

Study Design: Animal experimentation.

Effect of carnosine, methylprednisolone and their combined application on irisin levels in the plasma and brain of rats with acute spinal cord injury.

Spinal cord injury (SCI) might occur to anybody at any time and any age. In its treatment, methylprednisolone (MP) is a first choice worldwide, but there is still no significant breakthrough in truly beneficial treatment due to SCI's complex pathophysiology. We investigated the effect of carnosine, methylprednisolone (MP) and its combination on irisin levels in the plasma, brain and medulla spinalis tissues in SCI using a rat model.

Strontium substituted hydroxyapatites: Synthesis and determination of their structural properties, in vitro and in vivo performance.

The objective of this study is to present a detailed report related to the synthesis and characterization of strontium substituted hydroxyapatites. Based on this purpose, hydroxyapatite (HAp) bioceramics with different amounts of strontium (e.g.

Effects of bone drilling on local temperature and bone regeneration: an in vivo study.

Objective: The aim of this study was to examine the influence of bone drilling on local bone temperature and bone regeneration and determine optimal drilling speed and pressure in an animal model.

Methods: The study included 12 skeletally mature New Zealand white rabbits, weighing between 2.8 to 3.

Brain death scintigraphy and pathology results in a rat model.

Objectives: Brain scintigraphy with Tc-99m-labeled diethylenetriaminopenta-acetic acid is a sensitive diagnostic method showing loss of cerebral blood flow that occurs after brain death. Cerebral blood flow can be quantitatively estimated by this method. The aim of this study was to compare histopathologic changes occurring with the decrease of cerebral blood flow (as shown by Tc-99m-labeled diethylenetriaminopenta-acetic acid brain death scintigraphy) after brain death in an experimental model.

An alternative method in fixation of tibial transverse fractures by intramedullar nailing: biomechanical and histopathologic investigation.

A new method was used in fixation of tibial bone fractures. Intramadular nailing (IMN) has been used into mid-diaphysis on left tibias of New Zeland rabbits (n = 5) via an in vivo work. To enable fixation of fracture, without causing too much screw damage on bone and avoiding malunion, nano- and micro-scale hydroxyapatite (HA) was coated at two ends (25 mm in length) of intramadular nails before implantation.