Publications by authors named "Mustafa Gokkaya"
Determination of nuclear and/or cytoplasmic expression of β-catenin by immunohistochemistry in patients with endometrial cancer (EC) may constitute a potential diagnostic method for identifying patients with a catenin β1 (CTNNB1) gene mutation and those at risk of disease recurrence. The present study aimed to investigate β-catenin expression patterns in hysterectomy specimens of patients with endometrioid type EC using immunohistochemistry, and to examine the prognostic impact of β-catenin. The study was a single-institutional, retrospective cohort trial enrolling consecutive patients with a postoperative histopathological diagnosis of endometrioid EC who underwent hysterectomy between January 2015 and December 2018.
View Article and Find Full Text PDFObjective: We aimed to investigate differences between HPV-16 mono- and HPV-16/18 co-infections in terms of cervical dysplasia and invasive cancer.
Methods: This multicentre, retrospective study spanned from December 2017 to December 2020, involving women who visited gynaecological oncology clinics for colposcopy with either HPV-16 or HPV-16/18 positivity. A total of 736 patients, 670 in Group 1 (HPV-16 positivity) and 66 in Group 2 (HPV-16/18 positivity), were compared for the presence of CIN2+ lesions detected by colposcopic biopsy or endocervical curettage (ECC).
Despite the theoretical benefits, the favorable effect of preoperative carbohydrate loading on postoperative morbidity remains controversial. Most of the outcomes reported in the literature are derived from non-gynecologic surgery data, with only one study involving a limited number of patients specifically in gynecological oncology. The present study aimed to investigate the impact of carbohydrate loading, as a single element of enhanced recovery after surgery protocols, on postoperative course and morbidity in patients undergoing debulking surgery for epithelial ovarian cancer (EOC).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates clinical, surgical, and pathological factors in patients with stage 1C adult granulosa cell tumors (AGCT), focusing on the role of adjuvant therapy in recurrence and survival rates.
- Out of 415 patients treated, 63 met the criteria for stage 1C AGCT, and comparisons were made between those receiving adjuvant chemotherapy and those who did not, measuring disease-free survival (DFS) outcomes.
- Findings showed that adjuvant chemotherapy did not significantly affect DFS or overall survival, indicating a need for further multicentric and randomized studies to validate these conclusions.
Article Synopsis
- The study focuses on analyzing Pap smear results that show atypical glandular cells, not otherwise specified (AGC-NOS), to identify potential cervical and endometrial lesions.
- A total of 254 women who had AGC-NOS results and subsequently underwent colposcopy were reviewed, revealing that around 27.6% had premalignant or malignant lesions, including 6.7% with actual malignancies.
- The findings suggest that careful evaluation of patients with AGC-NOS is crucial, with a recommendation for colposcopic examination and potential endometrial sampling to detect any underlying cancers.