Behavior of the different implant materials in acute infection and efficacy of antibiotherapy: experimental study in rats.

In this study, we propose a comparison of the behaviors of four different implant materials in case of acute infection: expanded polytetrafluoroethylene (e-PTFE), porous high density polyethylene (PHDPE), silicone, and autogenous cartilage tissue. The efficacy of prophylactic and therapeutic antibiotic therapies was also investigated in a rat model as four groups: group A, acute infection and no antibiotic therapy (n = 24); group B, acute infection and prophylactic antibiotic therapy (n = 24); group C, acute infection and therapeutic antibiotic therapy (n = 24); and control, no infection and no antibiotic therapy (n = 24). All materials with dimensions of approximately 1 x 1 cm(2) diameter were implanted separately under the dorsal skin of rats.