Orthodontic Alloy Wires and Their Hypoallergenic Alternatives: Metal Ions Release in pH 6.6 and pH 5.5 Artificial Saliva.

Legislative framework addresses the issues of alloy corrosion, demanding the restricted use of probable carcinogenic, mutagenic, and toxic-for-human-reproduction (CMG) metals like nickel, cobalt, and chromium and demanding the development of new biomaterials. The aim of this research was to evaluate and compare the ion release of standard dental alloys and their hypoallergenic equivalents. Six types of orthodontic alloy wires (nickel-titanium (NiTi), coated NiTi, stainless steel (SS), Ni-free SS, and cobalt-chromium (CoCr) and titanium-molybdenum (TMA) were immersed into artificial saliva of pH 5.

Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters.

The aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA), 7 subjects with adrenocortical carcinoma (ACC), and 13 control subjects with a normal adrenal cortex. The status of VEGF and endocan expression was determined by the proportions of cells staining on a scale ranging from negative (not staining at all) to strongly positive.

Effect of Anode Interfacial Modification by Self-Assembled Monolayers on the Organic Solar Cell Performance.

A series of self-assembled monolayer (SAM)-based benzoic acid derivatives such as 4-[5'-phenyl-2,2'-bitien-5-yl] benzoic acid (ZE-Ph), 4-[5'-(4-fluorophenyl)-2,2'-bitien-5-yl]benzoic acid (ZE-1F), and 4-[5'-(3,5-difluorophenyl)-2,2'-bitien-5-yl]benzoic acid (ZE-2F) were synthesized to use an interlayer between an ITO electrode and a MoO thin film layer in an organic solar cell (OSC) having poly-3 hexylthiophene (P3HT): [6,6]-phenyl C butyric acid methyl ester (PCBM) blend. The work function and surface wetting properties of the ITO were tuned by SAM molecules. The power conversion efficiency of fabricated OSC devices was improved compared to that of the control device from 1.

Monodentate versus Bidentate Anchoring Groups in Self-Assembling Molecules (SAMs) for Robust p-i-n Perovskite Solar Cells.

Current improvement in perovskite solar cells (PSCs) has been achieved by interface engineering and fine-tuning of charge-selective contacts. In this work, we report three novel molecules that can form self-assembled layers (SAMs) as an alternative to the most commonly used p-type contact material, PTAA. Two of these molecules have bidentate anchoring groups (MC-54 and MC-55), while the last one is monodentate (MC-45).

Structural Characterization of TRAF6 N-Terminal for Therapeutic Uses and Computational Studies on New Derivatives.

Tumor necrosis factor receptor-associated factors (TRAFs) are a protein family with a wide variety of roles and binding partners. Among them, TRAF6, a ubiquitin ligase, possesses unique receptor binding specificity and shows diverse functions in immune system regulation, cellular signaling, central nervous system, and tumor formation. TRAF6 consists of an N-terminal Really Interesting New Gene (RING) domain, multiple zinc fingers, and a C-terminal TRAF domain.

Expression of endocan and vascular endothelial growth factor and their correlation with histopathological prognostic parameters in pheochromocytoma.

Objective: Endocan and vascular endothelial growth factor (VEGF) are markers expressed in various cancer types that are highly vascular, and they have prognostic significance for these cancers. In this study, we aimed to show the expression of endocan and VEGF in pheochromocytoma tumor tissues and to evaluate their correlations with histopathological parameters.

Material And Methods: Thirty-eight patients who had been operated for pheochromocytoma were included in the study.

Evaluation of subclinical atherosclerosis in obese patients with three noninvasive methods: Arterial stiffness, carotid intima-media thickness, and biomarkers of endothelial dysfunction.

Objective: In this study, we aimed to evaluate subclinical atherosclerosis in patients with obesity who had cardiovascular disease risk indicators such as arterial stiffness, which is evaluated using pulse wave velocity (PWV), carotid intima-media thickness (CIMT), and biomarkers of endothelial dysfunction such as endocan, ADAMTS97, and ADAMTS9.

Subjects And Methods: Sixty obese subjects, including 23 subjects with body mass index (BMI) ≥ 40, 37 subjects with BMI ≥ 30 but < 40, and 60 age-and sex-matched control subjects, were included in our study. Serum endocan, ADAMTS97, and ADAMTS9 levels as well as PWV and CIMT measurements of the subjects in the obese and control groups were performed.

Optimization of Au(III) adsorption by the Taguchi method using pyrogallol functionalized silica nanoparticles.

Pyrogallol molecules were successfully immobilized onto aminopropyl molecule functionalized MCM41 nanoparticles to obtain a fast and high gold adsorption capacity. The Taguchi statistical method was used to determine the factors affecting the gold(III) adsorption efficiency. The effect of six factors, pH, rate, adsorbent mass, temperature, initial Au(III) concentration and time, each with 5 levels, on the adsorption capacity was investigated by forming an L25 orthogonal.

Electronic and optical aspects of novel quinoxaline derivatives as electron donor materials for bulk heterojunction solar cells.

In this paper, we design new forms of organic conjugated compounds-based quinoxaline derivatives. Specifically, we exploit density functional theory and time-dependent-density functional theory in order to study the structure, the optic, the electronic, the reorganization energy and the photovoltaic features of such new molecules. Particularly, all engineered compounds have a narrow band gap in the range of 0.

Expression of the angiogenesis markers endocan in Cushing's syndrome due to cortisol producing adenoma.

Purpose: In this study, we aimed to investigate the endocan expression in tissue samples of patients diagnosed with Cushing's syndrome (CS) due to Cortisol-Producing-Adenoma (CPA) and compare it with normal adrenal cortex tissue, and also to evaluate the correlations of endocan expression with clinical and histopathological features.

Methods: 11 patients who were operated for CS due to CPA between 2009-2021 and 14 control subjects with normal adrenal cortex were included in the study. Demographic, laboratory and clinicopathological data of the patients were recorded.

Colorimetric detection of HO with FeO@Chi nanozyme modified µPADs using artificial intelligence.

Peroxidase mimicking FeO@Chitosan (FeO@Chi) nanozyme was synthesized and used for high-sensitive enzyme-free colorimetric detection of HO. The nanozyme was characterized in comparison with  FeO nanoparticles (NPs) using X-ray diffraction, Fourier-transform infrared spectroscopy, dynamic light scattering, and thermogravimetric analysis. The catalytic performance of FeO@Chi nanozyme was first evaluated by UV-Vis spectroscopy using 3,3',5,5'-tetramethylbenzidine.

Arterial Stiffness, Carotid Intima-Media Thickness, Endocan, and A Disintegrin and Metalloproteinase With Thrombospondin Type I Motif 9 Levels and Their Relationship With Disease Activity in Patients With Acromegaly With and Without Cardiovascular Risk Factors.

Objective: Cardiovascular complications such as cardiomyopathy and endothelial dysfunction, which are frequently seen in patients with acromegaly, are among the most important causes of morbidity and mortality. In this study, we aimed to investigate arterial stiffness, carotid intima-media thickness, endocan level, and A disintegrin and metalloproteinase with thrombospondin type I motif 9 level and their relationship with disease activity in patients with acromegaly with and without cardiovascular risk factors.

Methods: A total of 60 patients with acromegaly-25 with active disease, 26 with well-controlled disease, and 9 with newly diagnosed disease-and 60 age-, sex-, and body mass index (BMI)-matched healthy control subjects were enrolled in this study.

EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy.

Glioma, particularly its most malignant form, glioblastoma multiforme (GBM), is the most common and aggressive malignant central nervous system tumor. The drawbacks of the current chemotherapy for GBM have aroused curiosity in the search for targeted therapies. Aberrantly overexpressed epidermal growth factor receptor (EGFR) in GBM results in poor prognosis, low survival rates, poor responses to therapy and recurrence, and therefore EGFR-targeted therapy stands out as a promising approach for the treatment of gliomas.

Thyroid Nodules in Patients with Acromegaly: Frequency According to the ACR TI-RADS Classification and its Relationship with Disease Activity.

Purpose: In our study, we aimed to determine the frequency of thyroid nodules in patients with acromegaly according to the American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS) classification and its relationship with acromegaly disease activity.

Methods: A total of 56 patients with acromegaly and age, sex, and body mass index matched with 56 healthy control subjects were included in our study. Thyroid-stimulating hormone, free thyroxine, and anti-thyroperoxidase antibody levels of patients and control subjects were measured.

Increased incidence of malignancy in patients with primary hyperparathyroidism.

Background/aim: Primary hyperparathyroidism (PHPT) is a disease that is diagnosed more frequently and generally in the asymptomatic period, with widely available biochemical tests. Evidence suggesting an association between PHPT and malignancy risk is increasing. Clarification of this association will be useful in PHPT for malignancy screening and management of patients with PHPT.

Structure-Property Relationship in Amber Color Light-Emitting Electrochemical Cell with TFSI Counteranion: Enhancing Device Performance by Different Substituents on NN Ligand.

Amber color emitting novel Ir(III) complexes were synthesized: [Ir(Meppy)(Fpbpy)][PF] (PF), [Ir(Meppy)(Fpbpy)][TFSI] (TFSI), [Ir(Meppy)(MeObpy)][PF] (PF) and [Ir(Meppy)(MeObpy)][TFSI] (TFSI), where Meppy = 2-(-methylphenyl)-pyridine (), Fpbpy = 4,4'-bis(4-fluorophenyl)-2,2'-bipyridine (), and MeObpy = 4,4'-bis(4-methoxy)-2,2'-bipyridine (). The photophysical and X-ray results showed that the complexes have aggregation-induced phosphorescent emission (AIPE) and a salt-induced polymorphism effect. The highest photoluminescence intensity was observed in complex TFSI compared to other complexes in the solid state.

Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population.

Background/aim: The presence of comorbidities in patients with acromegaly causes an increase in morbidity and/or mortality and a decrease in quality of life. In this study, we aimed to investigate the demographic, clinical and laboratory features, prevalence of acro- megaly-related comorbidities, and factors associated with these comorbidities in patients with acromegaly.

Materials And Methods: In the study, 96 patients who were followed up with the diagnosis of acromegaly were included.

The relationship between glomerular filtration rate, and metabolic and inflammatory parameters in obese and non-obese patients with polycystic ovary syndrome.

Aim: To investigate the relationship between glomerular filtration rates (GFR), and homeostasis model assesment of insulin resistance (HOMA-IR), C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) in patients with polycystic ovary syndrome (PCOS).

Material And Methods: Thirty-one overweight and obese PCOS patients with body mass index (BMI)≥25kg/m and 25 non-obese PCOS patients with BMI<25kg/m were included into patients' group, while 23 overweight and obese, and 25 non-obese age-and BMI-matched healthy individuals (aged between 18 and 40 years), were enrolled as controls. Levels of serum creatinine, glucose, insulin, CRP, and complete blood count were measured.

The association of decreased testosterone with atherosclerosis and inflammation in male predialysis patients with chronic kidney disease.

Purpose: To investigate the frequency of hypogonadism and its relationship to inflammation and carotid intima-media thickness (CIMT) in male patients with predialysis chronic kidney disease (CKD).

Methods: A total of 105 patients with CKD, 55 (52.4%) as stage 3, 33 (31.