Identification of the molecular etiology in rare congenital hemolytic anemias using next-generation sequencing with exome-based copy number variant analysis.

Objectives: In congenital hemolytic anemias (CHA), it is not always possible to determine the specific diagnosis by evaluating clinical findings and conventional laboratory tests. The aim of this study is to evaluate the utility of next-generation sequencing (NGS) and clinical-exome-based copy number variant (CNV) analysis in patients with CHA.

Methods: One hundred and forty-three CHA cases from 115 unrelated families referred for molecular analysis were enrolled in the study.

Involutive sweeping surfaces with Frenet frame in Euclidean 3-space.

In this paper we first define the involutive sweeping surfaces as a new surface form. We then investigate singularity, Gaussian and mean curvatures of these surfaces. By calculating the Gaussian and mean curvatures of the involutive sweeping surfaces, we find necessary conditions of being flat or minimal of these surfaces.

Anxiety and theory of mind: A moderated mediation model of mindfulness and gender.

This study aimed to examine the relationship between gender, anxiety, mindfulness, and theory of mind (ToM). It was also aimed to investigate the mediating role of mindfulness in the relationship between anxiety and ToM. Additionally, the moderating role of gender in the relevant relationships was examined.

Nitric oxide, asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in psychotic exacerbation of schizophrenia and bipolar disorder manic episode.

Objectives: To examine the changes in nitric oxide (NO), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in schizophrenia during acute psychotic exacerbation and in bipolar disorder during mania and to compare those changes to healthy controls.

Methods: Thirty schizophrenia patients with acute psychotic exacerbation and 30 bipolar disorder patients with mania, who attended the Psychiatry Department,  Erenköy Hospital for Mental and Nervous Diseases, Istanbul, Turkey, in 2010. Thirty healthy controls were included.

Synthesis of magnetic halloysite nanotube-based molecularly imprinted polymers for sensitive spectrophotometric detection of metoclopramide in urine samples.

A novel molecularly imprinted polymer was synthesized on magnetic halloysite nanotube via surface initiated reversible addition-fragmentation chain transfer polymerization in the presence of 2-aminoethylmethacrylamide, 2-Cyano-2-propyl benzodithioate, ethylene glycol dimethacrylate (EGDMA) and azobis(isobutyronitrile) for sensitive and selective spectrophotometric determination of metoclopramide in urine samples. The synthesized imprinted polymer was characterized by several surface characterization techniques and the results indicated there was a thin polymer network on the magnetic halloysite nanotube. The rebinding properties of the molecularly imprinted magnetic halloysite nanotube were also investigated in detail and the maximum adsorption capacity and imprinting factor were found to be 37.

Efficient and selective separation of metronidazole from human serum by using molecularly imprinted magnetic nanoparticles.

Magnetic molecularly imprinted nanoparticles were prepared through surface-initiated reversible addition fragmentation chain transfer polymerization by using metronidazole as a template. The molecularly imprinted magnetic nanoparticles were characterized by attenuated total reflection Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, X-ray diffraction, and vibrating sample magnetometry. The adsorption characteristics were also investigated and the kinetics of the adsorption of metronidazole on the imprinted nanoparticles were described by the second-order kinetic model with the short equilibrium adsorption time (30 min).

Evaluation of childhood trauma with respect to criminal behavior, dissociative experiences, adverse family experiences and psychiatric backgrounds among prison inmates.

Objective: To evaluate childhood trauma in relation to criminal behavior, dissociative experiences, adverse family experiences during childhood and psychiatric backgrounds among prison inmates.

Methods: In total, 200 prison inmates were included in this questionnaire-based study. Data on demographic characteristics, adverse family experiences during childhood and psychiatric backgrounds were collected via face-to-face interviews, and a psychometric evaluation was conducted using the Childhood Trauma Questionnaire (CTQ-28) and Dissociative Experiences Scale (DES).

Amniotic fluid oxidant-antioxidant status in foetal congenital nervous system anomalies.

Objective This study aimed to evaluate the oxidant-antioxidant status of amniotic fluid in pregnant women with foetal congenital malformations of the central nervous system. Methods We studied pregnant women with foetal congenital nervous system anomalies at 16-22 weeks' gestation (n = 36). The control group (n = 30) consisted of pregnant women at the same gestational age who underwent amniocentesis, resulting in a normal karyotype.

Electroacupuncture Therapy in Nicotine Dependence: A Double Blind, Sham-Controlled Study.

Introduction: The number of non-pharmacological controlled studies is insufficient in the treatment of nicotine dependence (ND). Nevertheless, non-pharmacological treatments, such as electroacupuncture (EA), are becoming increasingly popular in the treatment of ND. The aims of this study were to determine the efficacy and safety of "true EA therapy" (TEAT) compared to those of "sham EA therapy" (SEAT) in ND treatment.

Levels of nitric oxide, asymmetric dimethyl arginine, symmetric dimethyl arginine,and L-arginine in patients with obsessive-compulsive disorder.

Background/aim: We aimed to investigate and compare to healthy controls the variations in the levels of nitric oxide (NO), asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), and L-arginine levels in patients with obsessive-compulsive disorder (OCD).

Materials And Methods: We enrolled 30 patients with OCD and 30 healthy controls in the study consecutively. Diagnostic interviews of all participants were conducted with the Structured Clinical Interview for Axis I Disorders (SCID-I), and sociodemographic data of the participants were recorded.

Electroencephalography Spectral Power Density in First-Episode Mania: A Comparative Study with Subsequent Remission Period.

Introduction: Our aim in this study was to investigate spectral power density (PSD) in first-episode mania and subsequent remission period and to evaluate their difference.

Methods: Sixty-nine consecutive cases referring to our hospital within the previous 1 year, who were evaluated as bipolar disorder manic episode according to The Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) at the first episode and had the informed consent form signed by first degree relatives, were included in this study. Exclusion criteria included having previous depressive episode, using drugs which could influence electroencephalographic activity before electroencephalography (EEG), and having previous neurological disease, particularly epilepsy, head trauma, and/or loss of consciousness.

Effects of paliperidone extended release on functioning level and symptoms of patients with recent onset schizophrenia: An open-label, single-arm, flexible-dose, 12-months follow-up study.

Background: Response to antipsychotic treatment is better in the early stages of schizophrenia.

Aims: The primary objective of this non-randomized, single-arm, multicenter clinical trial was to explore the response to treatment and safety of a flexible dose of paliperidone (mean = 6.42 mg/day) in patients with recent onset schizophrenia (< 3 years after the first episode/hospitalization).

Comparison of Sexual Function and Hormonal Parameters Between Mood Stabilizer Treatment Modalities in Bipolar Disorder.

Introduction: The aim of this study was to determine the differences between lithium and atypical antipsychotics (quetiapine and olanzapine) with regard to their effects on sexual functions and hormonal variables and to assess the findings in term of gender differences, in patients with bipolar disorder.

Method: 28 female and 29 male patients diagnosed as having bipolar disorder type I according to the DSM-IV, using lithium or quetiapine and quetiapine+lithium or olanzapine and olanzapine+lithium were evaluated consecutively. Being in remission period and given informed consent were set as inclusion criteria in these cases.

[ADHD in adult psychiatric outpatients: prevalence and comorbidity].

Aim: This study aimed to investigate the prevalence of attention-deficit/hyperactivity disorder (ADHD) in adult psychiatric outpatients. Moreover, comorbid psychiatric diagnoses in adults with ADHD were determined. Patients with and without ADHD were compared regarding DSM Axis I-II comorbidity and sociodemographic characteristics.

Extraordinary cause of complete colonic obstruction in children: urinary retention.

Complete colonic obstruction in children may occur secondary to congenital, and acquired factors related to the gastrointestinal system. Herein, we report an extraordinary presentation of complete colonic obstruction due to extensive urinary retention in a 3-year-old boy. The possible underlying mechanism was detected as urinary infection in a child with horseshoe kidney.

Clinical, psychological and maternal characteristics in early functional constipation.

Background: This cross-sectional study investigated the clinical features of functional constipation (FC) at preschool age, as well as emotional and behavioral characteristics of the children, psychological symptom level and parental attitudes of the mothers, and compared these with that of non-referred typically developing controls with normal intestinal habits.

Methods: Participants included 65 children with FC (mean age, 43.6 ± 15.

Clinical, Neurocognitive, Structural Imaging and Dermatogliphics in Schizophrenia According to Kraepelin Criteria.

Introduction: A century ago, Kraepelin stated that the distinctive feature of schizophrenia was progressive deterioration. Kraepelin criteria for schizophrenia are: (1) continuous hospitalization or complete dependence on others for obtaining basic necessities of life, (2) unemployment and (3) no remission for the past five years. We aimed to determine the clinical appearance and structural biological features of Kraepelinian schizophrenia.

Rare case of an abdominal mass presenting as acute abdomen: torsion of the vermiform appendix.

Torsion of the vermiform appendix is a rarely observed acute abdominal emergency. The clinical manifestations are similar to acute appendicitis. It should be included in the differential diagnosis if a patient presents with intermittent abdominal pain and an acute abdominal emergency.

Stupor due to possible interaction between Lorazepam and valproic acid: report of two cases.

Valproate (VPA) and lorazepam are excreted mainly by glucuronide conjugation. VPA reduces the excretion of lorazepam as a result of the administration of these two medications together. As a result of these interactions, even if rarely, serious adverse effects such as coma may develop.

Low plasma adiponectin levels in panic disorder.

Background: The present study was performed to evaluate plasma adiponectin levels in the patients with PD.

Method: The study group included a total of 28 patients (17 females, 11 males) and 23 age- and sex-matched healthy comparison subjects (10 females and 13 males). The plasma fasting glucose, total cholesterol, triglyceride, low density lipoprotein (LDL), high density lipoprotein (HDL), and hemoglobin were measured.

The prevalence of parasomnias in preadolescent school-aged children: a Turkish sample.

Study Objectives: To survey the prevalence of parasomnias in a population of children aged 7 to 11 years and to determine whether parasomnias are associated with medical and neurobehavioral properties.

Design: Parents and children completed a pediatric sleep questionnaire that contains 27 items developed by the authors to assess parasomnias in children. Parents and children were also interviewed about the children's medical and sociofamilial history, schooling, psychological difficulties, medication intake, and the history of psychomotor and psychosocial development.

[Tobacco, alcohol and substance use prevalence among elementary and secondary school students in nine cities of Turkey].

Objective: Previous studies in Turkey regarding substance use have failed to take into consideration the elementary school students. The purpose of the present study is to determine prevalence of tobacco, alcohol, and substance use among elementary and secondary school students in Turkey.

Method: The study was conducted in 9 big cities that were selected from different geographic regions of Turkey.