The First Molecular Detection of in Sudan Associates with Increased Outbreaks of Chikungunya and Dengue.

As part of our surveys of the invasive malaria vector in four Sudanese states, including North and South Kordofan, Sennar, and White Nile, we collected 166 larvae. Our morphological identification confirmed that 30% of the collected mosquito samples were species, namely and , while the 117 specimens were (39%), (32%), (9%), (9%), (6%), (3%), and (3%). Considering the serious threat of emergence for the public health in the area and our limited resources, we prioritized samples for further genomic analysis.

Spatiotemporal mapping of malaria incidence in Sudan using routine surveillance data.

Malaria is a serious threat to global health, with over [Formula: see text] of the cases reported in 2020 by the World Health Organization in African countries, including Sudan. Sudan is a low-income country with a limited healthcare system and a substantial burden of malaria. The epidemiology of malaria in Sudan is rapidly changing due to factors including the rapidly developing resistance to drugs and insecticides among the parasites and vectors, respectively; the growing population living in humanitarian settings due to political instability; and the recent emergence of Anopheles stephensi in the country.

Blood meal profile and positivity rate with malaria parasites among different malaria vectors in Sudan.

Background: Malaria is a life-threatening public health problem globally with particularly heavy burden in the sub-Saharan Africa including Sudan. The understanding of feeding preference of malaria vectors on different hosts is a major challenge for hindering the transmission cycle of malaria. In this study, blood meals taken by blood-fed Anopheles mosquitoes collected from the field in malaria endemic areas of Sudan were analysed for source of blood meal and malaria parasite presence.

The Phylodynamic and Spread of the Invasive Asian Malaria Vectors, , in Sudan.

is an invasive Asian malaria vector that initially emerged in Africa in 2012 and was reported in Sudan in 2019. We investigated the distribution and population structure of throughout Sudan by using sequencing and molecular tools. We confirmed the presence of in eight border-states, identifying both natural and human-made breeding sites.

Assessment of genetic diversity of Plasmodium falciparum circumsporozoite protein in Sudan: the RTS,S leading malaria vaccine candidate.

Background: The currently used malaria vaccine, RTS,S, is designed based on the Plasmodium falciparum circumsporozoite protein (PfCSP). The pfcsp gene, besides having different polymorphic patterns, can vary between P. falciparum isolates due to geographical origin and host immune response.