Publications by authors named "Mustafa Abbass"
Article Synopsis
- Polycyclic aromatic hydrocarbons (PAHs), especially benzo [a]pyrene (BaP), are carcinogenic compounds found in tobacco smoke, affecting mammals through a pathway involving cytochrome P450 (CYP1A1), which is not present in C. elegans (roundworms).
- In C. elegans, BaP exposure leads to a decrease in lysosomal neutral lipids and the deletion of the cyp-35A2 gene increases neutral lipid metabolism.
- A dual-labelled reporter strain (cyp-35A2:mCherry; unc-47:GFP) has been developed to identify key regulators (elt-2, nhr-49, fos-1) of BaP metabolism
Benzo[a]pyrene (BaP) is bioactivated in most organisms by the cytochrome P450 (CYP) enzymes, mainly CYP1A1, ultimately resulting in the reactive metabolite BaP-7,8-dihydrodiol-9,10-epoxide (BPDE) capable of covalently binding to DNA and forming adducts. This step has been defined as the key process in cancer initiation in humans. However, limited knowledge is available about the consequences of BaP exposure in organisms lacking this classical CYP1A1 pathway, one example is the model nematode Caenorhabditis elegans.
View Article and Find Full Text PDFMicroplastic (MP) pollution is everywhere. In terrestrial environments, microfibres (MFs) generated from textile laundering are believed to form a significant component of MPs entering soils, mainly through sewage sludge and compost applications. The aim of this study was to assess the effect of MFs on a keystone soil organism.
View Article and Find Full Text PDFObjective: To evaluate the antibacterial activity of the extracts of Laurus nobilis against three Gram-positive bacteria (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212 and Staphylococcus epidermidis CIP 444) and two Gram-negative bacteria (Escherichia coli ATCC 35218 and Pseudomonas aeruginosa ATCC 27853). Also, the antibiofilm activity has been investigated against the biofilm produced by Staphylococcus epidermidis CIP 444.
Materials: The polysaccharides, essential oil, and fatty oils extracted from the plant were used in broth microdilution methods to study the minimal inhibitory concentration, and then the minimal bactericidal concentration was determined.