Controlled Delivery of Ketoconazole an Antifungal Agent from Uncemented Titanium Using a Layer-by-Layer Technique.

This study aims to evaluate the effectiveness of a layer-by-layer (LbL) technique for delivering ketoconazole to prevent fungi prosthetic joint infection (PJI) LbL assembly is a versatile technique for functionalizing biomaterial surfaces and engineering objects such as capsules and films through electrostatic attraction. This method involves the cyclic deposition of various materials onto substrates, allowing for the controlled growth of thin films. One of the key advantages of LbL assembly is its ability to create stable, nanoscale films with organized structures and customizable compositions on a range of substrates, which only need to carry electrostatic charges.

Recent Advances in the Discovery of CK2 Inhibitors.

CK2 is a vital enzyme that phosphorylates a large number of substrates and thereby controls many processes in the body. Its upregulation was reported in many cancer types. Inhibitors of CK2 might have anticancer activity, and two compounds are currently under clinical trials.

Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo{1,5-a}Pyrimidines as multikinase inhibitors.

Four new series 7a-e, 8a-e, 9a-e, and 10a-e of 7-aryl-3-substituted pyrazolo[1,5-a]pyrimidines were synthesized and tested for their RTK and STK inhibitory activity. Compound 7d demonstrated potent enzymatic inhibitory activity against TrkA and ALK2 with IC 0.087and 0.

Recent advances in the discovery of tropomyosin receptor kinases TRKs inhibitors: A mini review.

The tropomyosin receptor tyrosine kinases (TRKs) control the cell proliferation mainly in the nervous system and are encoded by NTRK genes. Fusion and mutation of NTRK genes were detected in various types of cancers. Many small molecules TRK inhibitors have been discovered during the last two decades and some of them have entered clinical trials.