Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the C677T Polymorphism: A Randomized Trial.

Methylenetetrahydrofolate reductase () C677T polymorphism associated with body fat accumulation could possibly trigger an inflammatory process by elevating homocysteine levels and increasing cytokine production, causing several diseases. This study aimed to evaluate the effects of food intervention, and not folate supplements, on the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in overweight and obese women with the C677T polymorphism. A randomized, double-blind eight-week clinical trial of 48 overweight and obese women was conducted.

α-Tocopherol influences glycaemic control and DNA methylation in overweight and obese women under an energy-restricted diet: a randomized, double-blind, exploratory, controlled clinical trial.

Background: Excess weight is a strong risk factor for the development of dysglycaemia. It has been suggested that changes in the metabolism microRNAs, small non-coding RNAs that regulate gene expression, could precede late glycaemic changes. Vitamin E in turn may exert important functions in methylation and gene expression processes.