Publications by authors named "Muskan Alad"
Biomolecules
November 2024
Article Synopsis
- - The study investigates the role of periostin (POSTN) in osteoarthritis (OA), finding it is increased in patients and linked to inflammation and cartilage breakdown, suggesting it could be a target for therapy.
- - Link N (LN), a peptide from link protein, is shown to have anabolic properties and can reduce inflammation and degradation in cartilage, leading the researchers to explore its effects on POSTN expression.
- - Experimental results reveal that LN can decrease POSTN expression and disrupt its signaling in chondrocytes, indicating it has potential as a therapeutic agent in treating OA by targeting POSTN.
Biomolecules
October 2024
Article Synopsis
- Intervertebral disc degeneration and pain are linked to the activation of the NLRP3 inflammasome and the processing of IL-1β, which involves Toll-like receptor stimulation and the CD14 receptor.
- The peptide Short Link N (sLN) has shown promise in reducing inflammation and pain in disc cells, but its exact mechanisms of action are not fully understood.
- This study found that sLN inhibited the activation of NFκB and Caspase-1, leading to lower levels of IL-1β, and demonstrated a direct interaction between sLN and CD14, suggesting sLN could be a potential treatment for disc-related pain.
