A Short Dynamic Scan Method of Measuring Bone Metabolic Flux Using [F]NaF PET.

[F]NaF PET measurements of bone metabolic flux (K) are conventionally obtained with 60-min dynamic scans analysed using the Hawkins model. However, long scan times make this method expensive and uncomfortable for subjects. Therefore, we evaluated and compared measurements of K with shorter scan times analysed with fixed values of the Hawkins model rate constants.

Quantitative magnetization transfer imaging in Alzheimer disease.

Purpose: To prospectively measure magnetization transfer (MT) parameters, along with established atrophy parameters, in patients with Alzheimer disease (AD) and in age- and sex-matched control subjects.

Materials And Methods: Participants provided informed consent, and additional assent was obtained from next of kin of all patients with AD. The study was approved by the local ethics committee.

Application of automated medial temporal lobe atrophy scale to Alzheimer disease.

Objective: To compare an automated intensity-based measure of medial temporal atrophy in Alzheimer disease (AD) with existing volumetric and visually based methods.

Design: Longitudinal study comparing a medial temporal atrophy measure with 2 criterion standards: (1) total hippocampal (HC) volume adjusted for total intracranial volume and (2) standard visual rating scale of medial temporal atrophy.

Setting: Cognitive disorders specialist clinic.