IL-17 Control of Cutaneous Immune Homeostasis.

IL-17 is widely recognized for its roles in host defense and inflammatory disorders. However, it has become clear that IL-17 is also an essential regulator of barrier tissue physiology. Steady-state microbe sensing at the skin surface induces low-level IL-17 expression that enhances epithelial integrity and resists pathogens without causing overt inflammation.

Maximizing tendency predicts university adjustment and academic performance.

Introduction: Decision-making characteristics that contribute to university adjustment and academic performance have been important topics in the research on success in higher education. This study proposes a new perspective that maximizing tendency, as a decision-making style, influences adaptive outcomes in college life.

Materials And Methods: Two studies were performed to investigate the positive effects of maximizing tendency on university adjustment and academic performance.

Local IL-23 is required for proliferation and retention of skin-resident memory T17 cells.

The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which IL-23 supports tissue-specific immunity remains unclear. In mice, we found that circulating memory T cells were dispensable for anamnestic protection from skin infection, and tissue-resident memory (T) cell-mediated protection from reinfection required IL-23. Administration of anti-IL-23 receptor antibody to mice after resolution of primary infection resulted in loss of CD69 CD103 tissue-resident memory T helper 17 (T) cells from skin, and clinical anti-IL-23 therapy depleted T cells from skin of patients with psoriasis.